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Topotecan HCL

CAS 119413-54-6C23H24ClN3O5MW 457.9

Topotecan HCL (CAS 119413-54-6) — formula C23H24ClN3O5, molecular weight 457.9; category organic chemicals.

Specifications

CAS Number119413-54-6
Molecular FormulaC23H24ClN3O5
Molecular Weight457.9
CategoryOrganic Chemicals

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What this product is

Topotecan HCL is a carbon-based organic compound with CAS registry number 119413-54-6 and molecular formula C23H24ClN3O5 (molecular weight 457.9), belonging to the organic chemicals segment of chemical raw materials.

Identification

CAS number: 119413-54-6

Its molecular formula C23H24ClN3O5 comprises 23 C, 24 H, 1 Cl, 3 N, 5 O atoms.

Also known as: Topotecan HCL · Topotecan Hydrochloride

Category: organic chemicals

Frequently Asked Questions

What is the CAS number of Topotecan HCL?

The CAS registry number of Topotecan HCL is 119413-54-6.

What is the molecular formula and molecular weight of Topotecan HCL?

Molecular formula C23H24ClN3O5, molecular weight 457.9.

What other names is Topotecan HCL known by?

It is also registered under: Topotecan HCL, Topotecan Hydrochloride.

Which category does Topotecan HCL belong to?

Category: Organic Chemicals.

PubChem Public Data

Public-database records for Topotecan HCL (CAS 119413-54-6), reproduced here for independent cross-checking.

Safety classification and hazard statements

Reported hazard statementsH300 (37.5%), H301 (12.5%), H302 (12.5%), H315 (12.5%), H319 (12.5%), H335 (12.5%), H340 (87.5%), H350 (50%)

H300 (37.5%): Fatal if swallowed [Danger Acute toxicity, oral]

H301 (12.5%): Toxic if swallowed [Danger Acute toxicity, oral]

Physical description and handling notes

  • 211.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

How this substance is indexed

CAS Registry Number119413-54-6
PubChem CID60699
分子式C23H24ClN3O5
IUPAC 名称(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride
UNII(FDA)956S425ZCY

Documented uses

  • Breast Feeding; Lactation; Antineoplastic Agents; Topoisomerase I Inhibitors
  • Hycamtin (Topotecan Hydrochloride)
  • Topotecan hydrochloride is approved to be used alone or with other drugs to treat:
  • • Cervical cancer that has spread to other parts of the body, has come back, or cannot be cured with other therapy. It is used with cisplatin.
  • • Ovarian cancer that has spread to other parts of the body. It is used alone in patients whose cancer got worse during or after other chemotherapy.
  • • Small cell lung cancer that is platinum sensitive. It is used alone in patients whose cancer got worse after first-line chemotherapy.

Names this substance appears under

TOPOTECAN HYDROCHLORIDE; 119413-54-6; Topotecan Hcl; Nogitecan hydrochloride; Evotopin; Topotecan teva; Topotecan Actavis; Topotecan Hospira; SK&F S-104864-A; potactasol; NSC-759263; DTXSID1045952; SK&F-S-104864-A; Topotecan (as hydrochloride); 956S425ZCY; Hydrochloride, Nogitecan

Computed molecular descriptors

分子量457.9
氢键供体数3
氢键受体数7
可旋转键数3
精确质量457.1404486
单同位素质量457.1404486
拓扑极性表面积103
重原子数32
形式电荷0
复杂度867

Database abstract

Topotecan HCL · CAS 119413-54-6 · C23H24ClN3O5. UNII 956S425ZCY.

Source: PubChem / Wikidata; the batch COA governs where values differ.

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