2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide monohydrochloride

2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide monohydrochloride（CAS 3092-17-9）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Solid
• Soluble
• Specific optical rotation = +138.5 deg at 20 °C/D (concentration = 0.5 in chloroform)
• When heated to decomposition, material emits toxic fumes of nitrogen oxides and hydrogen chloride.
• pKa = 7.8 (0.3% aqueous solution); pH 3.5 to 5.5 (5% aqueous solution) /Midodrine hydrochloirde/
• 159.5 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID1047493]

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Synthesized from hydroquinone dimethyl ether by Friedel-Crafts acylation with chloroacetyl chloride, amination to the corresponding 2-aminoacetophenone, acylation at the amino function with chloroacetyl chloride, displacement of the chloro by the azido group and finally reduction with, e.g., sodium borohydride and catalytic hydrogenation (Pd/C).
• For the treatment of symptomatic orthostatic hypotension (OH).
• FDA proposed to withdraw approval of the drug midodrine hydrochloride, used to treat the low blood pressure condition, orthostatic hypotension, because required post-approval studies that verify the clinical benefit of the drug have not been done. To date, neither the original manufacturer nor any generic manufacturer has demonstrated the drug's clinical benefit, for example, by showing that use of the drug improved a patient's ability to perform life activities.
• ...used as a vasoconstrictor agent in the treatment of hypotension

它在各数据库里的别名

midodrine; 42794-76-3; Midodrin; Midodrina; Midodrinum; Midodrinum [INN-Latin]; St 1085; ST-1085; 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol; DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid; 6YE7PBM15H; Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamid; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethylacetamide; 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide; CHEBI:6933

计算机算出的分子描述符

数据库摘要

2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide monohydrochloride · CAS 3092-17-9 · C12H18N2O4. UNII 6YE7PBM15H. 熔点: 200; 熔点: 150 °C; 熔点: 200 - 203 °C.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。