4-ethoxyphenylurea

Public-database records for 4-ethoxyphenylurea (CAS 150-69-6), reproduced here for independent cross-checking.

Safety classification and hazard statements

Regulatory listings

Physical description and handling notes

• Dulcin appears as white crystals. (NTP, 1992)
• Solid
• White needle-like crystals or powder
• Lustrous needles
• Leafs (from dilute alcohol), plates (from water)
• Very sweet taste, about 250 times as sweet as sugar cane

Reported physical properties

How this substance is indexed

Documented uses

• Artificial sweetening agent, prohibited by FDA for use in foods.
• Food Additives -> SWEETENER -> JECFA Functional Classes
• ... Produced from the addition of potassium cyanate to p-phenetidine hydrochloride in aqueous solution at room temperature or from mixing urea and p-phenetidine hydrochloride to a mixture of hydrochloric acid and glacial acetic acid.
• Made by treating p-phenetidine with phosgene and then with ammonia.
• Dulcin achieved some practical importance as a sweetener, despite safety concerns. It was blended with saccharin or sodium saccharin in order to mask the aftertaste of saccharin. As some dulcin metabolites were considered potentially hazardous, it is now banned in most countries.
• Compared with dilute sucrose solutions, it is approximately 250 times sweeter. Sweetness characteristics are good.

Names this substance appears under

Dulcin; 150-69-6; 1-(4-Ethoxyphenyl)urea; (4-ethoxyphenyl)urea; N-(4-Ethoxyphenyl)urea; Sucrol; Valzin; p-Ethoxyphenylurea; Dulcine; Phenetolcarbamide; Suesstoff; p-Phenetolcarbamide; p-Phenetylurea; p-Phenetolecarbamide; 4-ETHOXYPHENYLUREA; p-Phenetolcarbamid

Computed molecular descriptors

Database abstract

4-ethoxyphenylurea · CAS 150-69-6 · C9H12N2O2. UNII 8U78KF577Z. 熔点: 343 to 345 °F (NTP, 1992); 熔点: 173.5 °C; 熔点: 173 - 174 °C.

Source: PubChem / Wikidata; the batch COA governs where values differ.