3,4-(Methylenedioxy)benzyl alcohol

Public-database records for 3,4-(Methylenedioxy)benzyl alcohol (CAS 495-76-1), reproduced here for independent cross-checking.

Safety classification and hazard statements

Regulatory listings

Physical description and handling notes

• Yellow powder; [Alfa Aesar MSDS]
• Needles from petroleum ether
• White to yellow powder, crystals or chunks
• Slightly soluble in water
• Soluble in ethanol, ethyl ether, benzene, chloroform, methanol; insoluble in ligroin
• Stable under recommended storage conditions.

Reported physical properties

How this substance is indexed

Documented uses

• The results indicate that two benzodioxole derivatives, piperonyl alcohol (PAL) and benzodioxole (BDO), are viable alternatives to conventional amines as coinitiator. The biocompatibility of benzodioxole derivatives makes them more promising than amine in dental resin formulations.
• 1,3-Benzodioxole-5-methanol: ACTIVE
• After oral administration of piperine (170 mg/kg) to rats, the metabolites in bile and urine were examined by thin-layer chromatography, high-performance liquid chromatography and combined gas chromatography-mass spectrometry. Four metabolites of piperine, viz. piperonylic acid, piperonyl alcohol, piperonal and vanillic acid were identified in the free form in 0-96 hr urine whereas only piperic acid was detected in 0-6 hr bile. ...
• The neolignan, burchellin, a natural compound that reduces urine excretion in larvae of the bloodsucking bug, Rhodnius prolixus, a vector of Chagas' disease, is rapidly degraded in the hemolymph of the insect. The main product that accumulates in this tissue has been shown to be piperonyl alcohol. Other catabolites have been identified by GC-MS analysis.

Names this substance appears under

Piperonyl alcohol; 495-76-1; Piperonol; 1,3-BENZODIOXOLE-5-METHANOL; 3,4-Methylenedioxybenzyl alcohol; 5-Hydroxymethyl-1,3-benzodioxole; Heliotropyl alcohol; 1-Hydroxymethyl-3,4-methylenedioxybenzene; Benzyl alcohol, 3,4-(methylenedioxy)-; DTXSID3060089; NSC-26265; 4163K563GS; RefChem:863613; DTXCID3040693; 207-808-4; 1,3-Benzodioxol-5-ylmethanol

Computed molecular descriptors

Database abstract

3,4-(Methylenedioxy)benzyl alcohol · CAS 495-76-1 · C8H8O3. UNII 4163K563GS. 沸点: BP: 157 °C at 16 mm Hg; 熔点: 58 °C; 蒸气压: 0.000254 [mmHg].

Source: PubChem / Wikidata; the batch COA governs where values differ.