2-hydroxy-4-(methylthio)butyric acid

Public-database records for 2-hydroxy-4-(methylthio)butyric acid (CAS 583-91-5), reproduced here for independent cross-checking.

Safety classification and hazard statements

Physical description and handling notes

• 2-hydroxy-4-(methylthio)-butanoic acid is a light brown liquid. (USCG, 1999)
• Light brown liquid; [CAMEO] Light brown to brown liquid with an odor of sulfur; [MSDSonline]
• Solid

Reported physical properties

How this substance is indexed

Documented uses

• Methionine hydroxy analog is used as a livestock dietary supplement; [Merck Index]
• Farming (Feed Additives) [Category: Industry]
• BLAKE, WINEMAN, US PATENTS 2,745,745 AND 2,938,053 (1956 AND 1960 TO MONSANTO)
• Butanoic acid, 2-hydroxy-4-(methylthio)-: ACTIVE
• CHICK LIVER HOMOGENATES CATALYZED THE OXIDATION OF 2-HYDROXY-4-(METHYLTHIO)BUTANOIC ACID TO KETOMETHIONINE & BOTH CHICK LIVER SUPERNATANTS & RAT LIVER SUPERNATANTS CONVERTED KETOMETHIONINE TO THE HYDROXY DERIVATIVE OR TO METHIONINE.
• IN RAT TISSUE, BOTH FLAVINE COENZYME & GLUTAMINE ARE REQUIRED FOR THE CONVERSION OF 2-HYDROXY-4-METHYLTHIOBUTYRIC ACID INTO METHIONINE. PER GRAM OF TISSUE, THE KIDNEY POSSESSES GREATER CONVERSION ACTIVITY THAN THE LIVER, BRAIN, SMALL INTESTINE, & MUSCLE, ALTHOUGH ON A TOTAL ORGAN BASIS THE LIVER IS THE MOST IMPORTANT. MOST OF THE CONVERSION ACTIVITY IS LOCATED IN THE SUPERNATANT FRACTION OF THE LIVER.

Names this substance appears under

2-Hydroxy-4-methylthiobutanoic acid; alpha-Hydroxy-gamma-methylmercaptobutyric acid; RefChem:585800; 4-methylthio-2-hydroxybutyrate; alpha-hydroxy-gamma-methylthiobutyrate; 2-Hydroxy-4-(methylthio)butyric acid; 583-91-5; Desmeninol; Alimet; 2-Hydroxy-4-(methylthio)butanoic acid; Desmeninol [INN]; Butanoic acid, 2-hydroxy-4-(methylthio)-; MHA acid; 2-hydroxy-4-(methylsulfanyl)butanoic acid; 2-hydroxy-4-methylsulfanylbutanoic acid; MHA-FA

Computed molecular descriptors

Database abstract

2-hydroxy-4-(methylthio)butyric acid · CAS 583-91-5 · C5H10O3S. UNII Z94465H1Y7. 熔点: 250 °C; 闪点: 250 °F (USCG, 1999); 密度: 1.21 to 1.23 (USCG, 1999).

Source: PubChem / Wikidata; the batch COA governs where values differ.