Halloysite（CAS 12068-50-7）：分子式 Al2H8O8Si2、分子量 246.19；类别 有机化学品。
登记用途：Uses: Chemically、the outer surface of the halloysite nanotubes has properties similar to SiO2 while the inner cylinder core is related to Al2O3. The charge (zeta potential) behavior of halloysite particles can be roughly described by superposition of mostly negative (at pH 6-7) surface potential of SiO2、with a small contribution from the positive Al2O3 inner surface.The positive (below pH 8.5) charge of the inner lumen promotes loading of halloysite nanotubes with negative macromolecules、which are at the same time repelled from the negatively charged outer surfaces. A wide range of active agents、including drugs、nicotinamide adenine dineculeotide (NAD)、and marine biocides、can be entrapped within the inner lumen、as well as within void spaces of the multilayered aluminosilicate shells. This entrapment can be followed by retention and release of the agents、making the halloysite a nanomaterial well suited for macromolecular delivery applications.、Both hydrophobic and hydrophilic agents can be entrapped after an appropriate pre-treatment of the halloysite surface. For example、the authors、recently demonstrated loading of the halloysite with urease for bio-catalytic CaCO3 synthesis in the tubule lumen. For hydrophilic molecules (like kellin、NAD、tetracycline) a typical release time was 2-5 hours and for molecules with low solubility in water (like dexamethasone、furosemide、nifedipine) release time 5-20 hours was observed . Macromolecular release profiles from the halloysite are well described by a one-dimensional diffusion model through the nanotube lumen opening.、A clay used in refractories and as a catalyst support、Used primarily in whiteware ceramics as an additive where it adds dry and fired strength and makes the dinnerware more translucent ... also used in paper and as a raw material to make synthetic zeolites.、For more Uses (Complete) data for Halloysite (7 total)、please visit the HSDB record page.、General Manufacturing Information: Halloysite、a naturally occurring aluminosilicate nanotube、has been undeservedly forgotten. Halloysite (Al2Si2O5(OH)4*2H2O) is a two-layered aluminosilicate、with a predominantly hollow tubular structure in the submicron range and chemically similar to kaolin. The neighboring alumina and silica layers、and their waters of hydration、curve and form multilayer tubes due to a packing disorder. Halloysite is an economically viable material that can be mined from the corresponding deposit as a raw mineral. As for most natural materials、the size of halloysite particles varies within 1-15 microns of length and 10-150 nm of inner diameter、depending on the deposits.、The authors、studied loading and release of macromolecules from the halloysite nanotubules. Loading was performed as follows: A vial containing the mixture of halloysite and saturated solution of targeted molecules was transferred to a vacuum jar and then repeatedly evacuated using a vacuum pump. Slight fizzing of the suspension indicates the air being removed from the halloysite interior. After the fizzing stopped、the vial was sealed for 30 minutes to reach equilibrium in molecule distribution. The halloysite suspension was centrifuged to remove excess dissolved molecules and washed. The process may be repeated twice to ensure that the halloysite is filled with the maximum amount of the targeted molecules. With this simple loading technique、one can fill nanotubule lumen with any materials、such as drugs、proteins、polyelectrolytes、and nanoparticles of proper diameter using old-fashioned method similar to muzzle loading with bullets.、The most important members of the kaolin sub group of minerals are kaolinite and halloysite. Kaolinite has the formula Al2Si2O5(OH)4 and typically occurs in platy forms. Halloysite has a similar composition except that it contains additional water molecules between the layers and most commonly has a tubular morphology. Halloysite loses its interlayer water very easily so it is often observed in a partly dehydrated state. In its fully hydrated form the formula is Al2Si2O5(OH)4 -2H2O. Kaolinite is a very important industrial mineral、and halloysite is becoming increasingly important due mainly to its use in nanotechnology applications which take advantage of its tubular habit.、Halloysite is a member of the kaolin group and has a layer of water between the unit layers. This causes the shape to be elongate tubes、which greatly changes its applications. ... Produced mainly in New Zealand。
Halloysite 是一种以碳骨架为基础的有机化合物，登记 CAS 号为 12068-50-7，分子式 Al2H8O8Si2（分子量 246.19），归属于有机化学品大类化工原料。
登记 CAS 号：12068-50-7
其分子式 Al2H8O8Si2 由 2 个铝、8 个氢、8 个氧、2 个硅 组成。
别名/同义词：Halloysite · kaolin
所属分类：有机化学品
Halloysite 的 CAS 登记号为 12068-50-7。
分子式 Al2H8O8Si2，分子量 246.19。
别名/同义词：Halloysite、kaolin。
登记用途：Uses: Chemically、the outer surface of the halloysite nanotubes has properties similar to SiO2 while the inner cylinder core is related to Al2O3. The charge (zeta potential) behavior of halloysite particles can be roughly described by superposition of mostly negative (at pH 6-7) surface potential of SiO2、with a small contribution from the positive Al2O3 inner surface.The positive (below pH 8.5) charge of the inner lumen promotes loading of halloysite nanotubes with negative macromolecules、which are at the same time repelled from the negatively charged outer surfaces. A wide range of active agents、including drugs、nicotinamide adenine dineculeotide (NAD)、and marine biocides、can be entrapped within the inner lumen、as well as within void spaces of the multilayered aluminosilicate shells. This entrapment can be followed by retention and release of the agents、making the halloysite a nanomaterial well suited for macromolecular delivery applications.、Both hydrophobic and hydrophilic agents can be entrapped after an appropriate pre-treatment of the halloysite surface. For example、the authors、recently demonstrated loading of the halloysite with urease for bio-catalytic CaCO3 synthesis in the tubule lumen. For hydrophilic molecules (like kellin、NAD、tetracycline) a typical release time was 2-5 hours and for molecules with low solubility in water (like dexamethasone、furosemide、nifedipine) release time 5-20 hours was observed . Macromolecular release profiles from the halloysite are well described by a one-dimensional diffusion model through the nanotube lumen opening.、A clay used in refractories and as a catalyst support、Used primarily in whiteware ceramics as an additive where it adds dry and fired strength and makes the dinnerware more translucent ... also used in paper and as a raw material to make synthetic zeolites.、For more Uses (Complete) data for Halloysite (7 total)、please visit the HSDB record page.、General Manufacturing Information: Halloysite、a naturally occurring aluminosilicate nanotube、has been undeservedly forgotten. Halloysite (Al2Si2O5(OH)4*2H2O) is a two-layered aluminosilicate、with a predominantly hollow tubular structure in the submicron range and chemically similar to kaolin. The neighboring alumina and silica layers、and their waters of hydration、curve and form multilayer tubes due to a packing disorder. Halloysite is an economically viable material that can be mined from the corresponding deposit as a raw mineral. As for most natural materials、the size of halloysite particles varies within 1-15 microns of length and 10-150 nm of inner diameter、depending on the deposits.、The authors、studied loading and release of macromolecules from the halloysite nanotubules. Loading was performed as follows: A vial containing the mixture of halloysite and saturated solution of targeted molecules was transferred to a vacuum jar and then repeatedly evacuated using a vacuum pump. Slight fizzing of the suspension indicates the air being removed from the halloysite interior. After the fizzing stopped、the vial was sealed for 30 minutes to reach equilibrium in molecule distribution. The halloysite suspension was centrifuged to remove excess dissolved molecules and washed. The process may be repeated twice to ensure that the halloysite is filled with the maximum amount of the targeted molecules. With this simple loading technique、one can fill nanotubule lumen with any materials、such as drugs、proteins、polyelectrolytes、and nanoparticles of proper diameter using old-fashioned method similar to muzzle loading with bullets.、The most important members of the kaolin sub group of minerals are kaolinite and halloysite. Kaolinite has the formula Al2Si2O5(OH)4 and typically occurs in platy forms. Halloysite has a similar composition except that it contains additional water molecules between the layers and most commonly has a tubular morphology. Halloysite loses its interlayer water very easily so it is often observed in a partly dehydrated state. In its fully hydrated form the formula is Al2Si2O5(OH)4 -2H2O. Kaolinite is a very important industrial mineral、and halloysite is becoming increasingly important due mainly to its use in nanotechnology applications which take advantage of its tubular habit.、Halloysite is a member of the kaolin group and has a layer of water between the unit layers. This causes the shape to be elongate tubes、which greatly changes its applications. ... Produced mainly in New Zealand。
所属分类：Organic Chemicals。
Halloysite（CAS 12068-50-7）的公开数据库记录，列此仅供独立核对。
| GHS 通报统计 | 37.5% (3 / 8) |
|---|---|
| 已通报的危害声明 | H373 (62.5%) |
| GHS 通报统计 | 37.5% (3 / 8) |
|---|
| CAS 号 | 12068-50-7 |
|---|---|
| PubChem CID | 6337008 |
| 分子式 | Al2H8O8Si2 |
Halloysite; 12298-43-0; Cuprohalloysite; Metahalloysite; Glagerite; Halloysite-7A; Hydrated halloysite; RefChem:145082; 686-506-8; Al2H8O8Si2; HPTYUNKZVDYXLP-UHFFFAOYSA-N
| 分子量 | 246.19 |
|---|---|
| 氢键供体数 | 7 |
| 氢键受体数 | 8 |
| 可旋转键数 | 2 |
| 精确质量 | 245.938847 |
| 单同位素质量 | 245.938847 |
| 拓扑极性表面积 | 132 |
| 重原子数 | 12 |
| 形式电荷 | 0 |
| 复杂度 | 72.1 |
埃洛石 · CAS 12068-50-7 · Al2H8O8Si2.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。