zofenopril

Description

zofenopril · CAS 81872-10-8 · C22H23NO4S2. UNII 290ZY759PI.

Identification

CAS Registry Number	81872-10-8
PubChem CID	92400
Molecular formula	C22H23NO4S2
IUPAC name	(2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
UNII (FDA)	290ZY759PI

Computed Descriptors

Molecular Weight	429.6
XLogP3	4.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	429.10685056
Monoisotopic Mass	429.10685056
Topological Polar Surface Area	125
Heavy Atom Count	29
Formal Charge	0

Documented Uses

• A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• C09 - Agents acting on the renin-angiotensin system
• QC09 - Agents acting on the renin-angiotensin system

Synonyms

Zofenopril; 81872-10-8; Zofenoprilum; Zofenil; DTXSID0046640; 290ZY759PI; SQ-26900; CHEBI:78539; DTXCID50153934; L-Proline, 1-(3-(benzoylthio)-2-methyl-1-oxopropyl)-4-(phenylthio)-, (1(R*),2alpha,4alpha)-; (2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid; Zofil; (2S,4S)-1-((2S)-3-(benzoylsulfanyl)-2-methylpropanoyl)-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid; (2S,4S)-1-((2S)-3-(benzoylsulfanyl)-2-methylpropanoyl)-4-phenylsulfanylpyrrolidine-2-carboxylic acid; (2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid; RefChem:196203

Frequently Asked Questions

What are the CAS number and molecular formula of zofenopril?

CAS 81872-10-8; molecular formula C22H23NO4S2; molecular weight — g/mol.

What other names is zofenopril known by?

Zofenopril, 81872-10-8, Zofenoprilum, Zofenil, DTXSID0046640, 290ZY759PI.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.