Zuclopenthixol

Description

Zuclopenthixol · CAS 53772-83-1 · C22H25ClN2OS. UNII 47ISU063SG. Melting Point: ~50; Solubility: 2.60e-03 g/L.

Identification

CAS Registry Number	53772-83-1
PubChem CID	5311507
Molecular formula	C22H25ClN2OS
IUPAC name	2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol
UNII (FDA)	47ISU063SG

Computed Descriptors

Molecular Weight	401.0
XLogP3	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	400.1376123
Monoisotopic Mass	400.1376123
Topological Polar Surface Area	52
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	~50
Solubility	2.60e-03 g/L

Physical description & handling notes

• Solid
• slight
• Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Used in the management of acute psychoses such as mania or schizophrenia. However, the use of zuclopenthixol acetate in psychiatric emergencies as an alternative to standard treatments (haloperidol, clotiapine, etc.) should be cautioned, since well executed and documented trials of zuclopenthixol acetate for this use have yet to be conducted. Zuclopenthixol acetate is not intended for long-term use.
• Breast Feeding; Lactation; Milk, Human; Antipsychotic Agents; Dopamine Antagonists
• Avoid alcohol. Acute alcohol intoxication is a contraindication for zuclopenthixol therapy.
• Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Synonyms

Zuclopenthixol; 53772-83-1; Clopixol; Zuclopentixol; Zuclopenthixolum; Clopentixol cis-(Z)-; 2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol; 47ISU063SG; (Z)-4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol; DTXSID3048233; CHEBI:51364; 2-(4-{3-[(9Z)-2-CHLORO-9H-THIOXANTHEN-9-YLIDENE]PROPYL}PIPERAZIN-1-YL)ETHAN-1-OL; zuclopentixolo; 2-(4-((3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol; 2-(4-(3-((9Z)-2-chloro-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethan-1-ol; Clopenthixol cis(z)-

Frequently Asked Questions

What are the CAS number and molecular formula of Zuclopenthixol?

CAS 53772-83-1; molecular formula C22H25ClN2OS; molecular weight — g/mol.

What other names is Zuclopenthixol known by?

Zuclopenthixol, 53772-83-1, Clopixol, Zuclopentixol, Zuclopenthixolum, Clopentixol cis-(Z)-.

Is Zuclopenthixol classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Zuclopenthixol?

Melting Point: ~50; Solubility: 2.60e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.