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Adefovir Dipivoxyl

CAS 142340-99-6C20H32N5O8PMW 501.5

Adefovir Dipivoxyl (CAS No. 142340-99-6) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number142340-99-6
Molecular FormulaC20H32N5O8P
Molecular Weight501.5
LogP1.91
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Adefovir Dipivoxyl?

The CAS number of Adefovir Dipivoxyl is 142340-99-6.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Adefovir Dipivoxyl?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Adefovir Dipivoxyl or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Adefovir Dipivoxyl · CAS 142340-99-6 · C20H32N5O8P. UNII U6Q8Z01514. Solubility: 19; Solubility: 6.33e-01 g/L; LogP: 1.91.

Identification

CAS Registry Number142340-99-6
PubChem CID60871
Molecular formulaC20H32N5O8P
IUPAC name[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
UNII (FDA)U6Q8Z01514

Computed Descriptors

Molecular Weight501.5
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count15
Exact Mass501.19884999
Monoisotopic Mass501.19884999
Topological Polar Surface Area167
Heavy Atom Count34
Formal Charge0

Physical & Chemical Properties

Solubility19
Solubility6.33e-01 g/L
LogP1.91
LogP0.8
LogP2.48

Physical description & handling notes

  • Solid
  • Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

GHS Hazard Classification

Reported hazard statementsH302 (100%), H312 (95.1%), H332 (97.6%), H311 (50%), H331 (50%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (95.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]

Documented Uses

  • Take with or without food. The absorption is unaffected by food.
  • Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
  • Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
  • Nucleoside Analog [EXT]; Nucleoside Reverse Transcriptase Inhibitors [MoA]; Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]
  • J - Antiinfectives for systemic use
  • J05 - Antivirals for systemic use

Synonyms

ADEFOVIR DIPIVOXIL; 142340-99-6; Hepsera; Adefovir pivoxil; GS-0840; GS 0840; DTXSID5046487; Adefovir di(pivaloyloxymethyl) ester; 9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; (((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate; U6Q8Z01514; DTXCID3026487; CHEBI:31175; adefovir depivoxil; RefChem:56260

Frequently Asked Questions

What are the CAS number and molecular formula of Adefovir Dipivoxyl?

CAS 142340-99-6; molecular formula C20H32N5O8P; molecular weight — g/mol.

What other names is Adefovir Dipivoxyl known by?

ADEFOVIR DIPIVOXIL, 142340-99-6, Hepsera, Adefovir pivoxil, GS-0840, GS 0840.

Is Adefovir Dipivoxyl classified as hazardous?

Hazard statements reported: H302, H312, H332, H311, H331.

What are the key physical properties of Adefovir Dipivoxyl?

Solubility: 19; Solubility: 6.33e-01 g/L; LogP: 1.91; LogP: 0.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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