CARBAMAZEPINE

Description

CARBAMAZEPINE · CAS 298-46-4 · C15H12N2O. UNII 33CM23913M. Boiling Point: 399.6±45.0; Melting Point: 189-192; Melting Point: 190.2 °C.

Identification

CAS Registry Number	298-46-4
PubChem CID	2554
Molecular formula	C15H12N2O
IUPAC name	benzo[b][1]benzazepine-11-carboxamide
UNII (FDA)	33CM23913M

Computed Descriptors

Molecular Weight	236.27
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	236.094963011
Monoisotopic Mass	236.094963011
Topological Polar Surface Area	46.3
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Boiling Point	399.6±45.0
Melting Point	189-192
Melting Point	190.2 °C
Solubility	1.52e-01 g/L
LogP	2.77
LogP	log Kow = 2.45
LogP	2.3
LogP	2.34
Ionization Efficiency	2.4
Ionization Efficiency	2.7

Physical description & handling notes

• Solid
• Crystals from absolute ethanol and benzene
• White to off-white powder
• Sol in alcohol, acetone, propylene glycol; practically insol in water
• Soluble in chloroform, dimethylformamide, ethylene glycol monomethyl ether, or methanol; only slightly soluble in ethanol or glacial acetic acid
• >35.4 [ug/mL] (The mean of the results at pH 7.4)

Regulatory Status

GHS notification summary	0.5% (1 / 210)

GHS Hazard Classification

GHS notification summary	0.5% (1 / 210)
Reported hazard statements	H302 (96.2%), H317 (94.3%), H334 (87.6%)

Documented Uses

• In the treatment of pain associated with trigeminal neuralgia
• Use (kg) in Switzerland (2009): >2500
• Use (kg; approx.) in Germany (2009): >50000
• Use (kg; exact) in Germany (2009): 64270
• Use (kg) in France (2004): 33514
• Consumption (g per capita) in Switzerland (2009): 0.32

Synonyms

carbamazepine; 298-46-4; Tegretol; 5H-Dibenz[b,f]azepine-5-carboxamide; Finlepsin; Tegretal; Carbamazepen; Carbazepine; Biston; Telesmin; Equetro; Timonil; Carbamezepine; Karbamazepin; Carbatrol; Neurotol

Frequently Asked Questions

What are the CAS number and molecular formula of CARBAMAZEPINE?

CAS 298-46-4; molecular formula C15H12N2O; molecular weight — g/mol.

What other names is CARBAMAZEPINE known by?

carbamazepine, 298-46-4, Tegretol, 5H-Dibenz[b,f]azepine-5-carboxamide, Finlepsin, Tegretal.

Is CARBAMAZEPINE classified as hazardous?

0.5% of GHS notifications report no hazard classification (1 of 210).

What are the key physical properties of CARBAMAZEPINE?

Boiling Point: 399.6±45.0; Melting Point: 189-192; Melting Point: 190.2 °C; Solubility: 1.52e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.