Cyclamic Acid

Description

Cyclamic Acid · CAS 100-88-9 · C6H13NO3S. UNII HN3OFO5036. Melting Point: 169.5 °C; Melting Point: 169 - 170 °C; Solubility: 1000000 mg/L @ 25 °C (exp).

Identification

CAS Registry Number	100-88-9
PubChem CID	7533
Molecular formula	C6H13NO3S
IUPAC name	cyclohexylsulfamic acid
UNII (FDA)	HN3OFO5036

Computed Descriptors

Molecular Weight	179.24
XLogP3	0.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	179.06161445
Monoisotopic Mass	179.06161445
Topological Polar Surface Area	74.8
Heavy Atom Count	11
Formal Charge	0

Physical & Chemical Properties

Melting Point	169.5 °C
Melting Point	169 - 170 °C
Solubility	1000000 mg/L @ 25 °C (exp)
Vapor Pressure	0.0000027 [mmHg]

Physical description & handling notes

• Large Crystals
• White odorless solid; [Hawley] Fine white crystals; [MSDSonline]
• Solid
• Crystals
• White crystalline powder
• Odorless

Regulatory Status

Regulatory & Food Contact	SWEETENER: Food Additives JECFA ADI: 0-11 mg/kg bw TRS 956-JECFA 71 FAS 62-JECFA 71
GHS notification summary	25% (7 / 28)

GHS Hazard Classification

GHS notification summary	25% (7 / 28)
Reported hazard statements	H315 (71.4%), H319 (71.4%)

Documented Uses

• Used as intermediate for its salts (non-caloric sweeteners); Used formerly as non-nutritive sweetener; [HSDB] Used as acidulant; [Hawley]
• Sodium and calcium cyclamates are used as non-nutritive sweeteners ... Calcium cyclamate is used in low-sodium and sodium-free products /Cyclamate salts/
• CHEM INT FOR SALTS (NONCALORIC SWEETENERS)
• The main application of cyclamates ... is in blends with saccharin in a 10:1 ratio by weight. In these blends, quantitative and qualitative synergistic effects can be used to advantage, rendering them an important sweetener system in countries approving the use of both sweeteners.
• Food Additives -> SWEETENER -> JECFA Functional Classes
• Cyclamic acid was synthesized by the reaction of barium-N-cyclohexylsulphamate (made by the sulphonation of cyclohexylamine with chlorosulphonic acid in chloroform followed by treatment with barium hydroxide) with sulphuric acid.

Synonyms

Cyclamic acid; Cyclohexylsulfamic acid; 100-88-9; N-Cyclohexylsulfamic acid; CYCLAMATE; Cyclohexanesulfamic acid; Hexamic acid; Sucaryl acid; Sucaryl; Cyclohexylaminesulphonic acid; Cyclohexylamidosulfuric acid; Cyclohexylaminesulfonic acid; Cyclohexylsulphamic acid; Cyclamsaeure; Cyclohexanesulphamic acid; Cyclohexylamidosulphuric acid

Frequently Asked Questions

What are the CAS number and molecular formula of Cyclamic Acid?

CAS 100-88-9; molecular formula C6H13NO3S; molecular weight — g/mol.

What other names is Cyclamic Acid known by?

Cyclamic acid, Cyclohexylsulfamic acid, 100-88-9, N-Cyclohexylsulfamic acid, CYCLAMATE, Cyclohexanesulfamic acid.

What is the regulatory status of Cyclamic Acid?

Documented regulatory listings: SWEETENER: Food Additives; JECFA ADI: 0-11 mg/kg bw; TRS 956-JECFA 71.

Is Cyclamic Acid classified as hazardous?

25% of GHS notifications report no hazard classification (7 of 28).

What are the key physical properties of Cyclamic Acid?

Melting Point: 169.5 °C; Melting Point: 169 - 170 °C; Solubility: 1000000 mg/L @ 25 °C (exp); Vapor Pressure: 0.0000027 [mmHg].

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.