柠檬酸二乙基卡巴嗪

Description

diethylcarbamazine citrate · CAS 1642-54-2 · C10H21N3O.C6H8O7. UNII OS1Z389K8S. Melting Point: 286 to 289 °F (EPA, 1998); Melting Point: 141-143 °C; Solubility: > 75% in water @ 20 °C.

Identification

CAS Registry Number	1642-54-2
PubChem CID	15432
Molecular formula	C10H21N3O.C6H8O7
IUPAC name	N,N-diethyl-4-methylpiperazine-1-carboxamide;2-hydroxypropane-1,2,3-tricarboxylic acid
UNII (FDA)	OS1Z389K8S

Computed Descriptors

Molecular Weight	391.42
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	391.19546489
Monoisotopic Mass	391.19546489
Topological Polar Surface Area	159
Heavy Atom Count	27
Formal Charge	0
Complexity	411

Physical & Chemical Properties

Melting Point	286 to 289 °F (EPA, 1998)
Melting Point	141-143 °C
Solubility	> 75% in water @ 20 °C

Physical description & handling notes

• Diethylcarbamazine citrate is a crystalline solid, scored white tablets. Used against filariasis in man and animals. (EPA, 1998)
• White, crystalline powder
• Odorless or slight odor
• Bitter acid taste
• Freely sol in hot alcohol
• Sparingly sol in cold alcohol

GHS Hazard Classification

Reported hazard statements	H302 (100%), H330 (100%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1): ACTIVE
• Filaricides; Lipoxygenase Inhibitors
• Dietylcarbamazine citrate is usually admin by mouth as tablets. ... It has also been given by intramuscular injection.
• For mass treatment /against microfilariae of Wucereria bancrofti and Wuchereria malayi/ with the objective of reducing microfilaremia to subinfective levels for mosquitoes, the dose is 2 mg/kg, three times daily after meals, for 7 days for treatment directed toward possible cure, this dosage regimen is carried out for 10 to 30 days. ... For practical purposes, an adequate amount seems to be a total dose of about 72 mg/kg of the citrate salt.
• For /treatment against Loa loa microfilariae/ a dose of 2 mg/kg should be given 3 times daily after meals for 2 to 3 weeks. If repeated courses are required to produce cure, they should be separated by periods of 3 to 4 weeks.

Synonyms

DIETHYLCARBAMAZINE CITRATE; 1642-54-2; Loxuran; Dicarocide; Banocide; Caritrol; Filazine; Franocide; Franozan; Carbam Palatabs; Ditrazin citrate; Ethodryl citrate; Dirocide; Ditrazine; Ditrazinum; Filarabits

Frequently Asked Questions

What are the CAS number and molecular formula of diethylcarbamazine citrate?

CAS 1642-54-2; molecular formula C10H21N3O.C6H8O7; molecular weight — g/mol.

What other names is diethylcarbamazine citrate known by?

DIETHYLCARBAMAZINE CITRATE, 1642-54-2, Loxuran, Dicarocide, Banocide, Caritrol.

Is diethylcarbamazine citrate classified as hazardous?

Hazard statements reported: H302, H330.

What are the key physical properties of diethylcarbamazine citrate?

Melting Point: 286 to 289 °F (EPA, 1998); Melting Point: 141-143 °C; Solubility: > 75% in water @ 20 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.