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Enasidenib

CAS 1446502-11-9C19H17F6N7OMW 473.4

Enasidenib (CAS No. 1446502-11-9) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Organic Chemicals. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1446502-11-9
Molecular FormulaC19H17F6N7O
Molecular Weight473.4
LogP3.5
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsOrganic Chemicals
CategoryOrganic Chemicals

Where it is used

Organic Chemicals

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Enasidenib?

The CAS number of Enasidenib is 1446502-11-9.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Enasidenib?

Main applications include Organic Chemicals.

How do I buy Enasidenib or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Enasidenib · CAS 1446502-11-9 · C19H17F6N7O. UNII 3T1SS4E7AG.

Identification

CAS Registry Number1446502-11-9
PubChem CID89683805
Molecular formulaC19H17F6N7O
IUPAC name2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol
UNII (FDA)3T1SS4E7AG

Computed Descriptors

Molecular Weight473.4
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count14
Rotatable Bond Count6
Exact Mass473.13987716
Monoisotopic Mass473.13987716
Topological Polar Surface Area109
Heavy Atom Count33
Formal Charge0

GHS Hazard Classification

Reported hazard statementsH360 (50%), H373 (100%), H413 (50%)

H360 (50%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H361f (50%): Suspected of damaging fertility [Warning Reproductive toxicity]

Documented Uses

  • Enasidenib is indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test.
  • Enasidenib is an orally available small molecule inhibitor of mutant isocitrate dehydrogenase-2 that is used in the therapy of selected cases of acute myelogenous leukemia (AML). Enasidenib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Isocitrate Dehydrogenase Inhibitors
  • Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
  • Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
  • Take at the same time every day.

Synonyms

Enasidenib; 1446502-11-9; CC-90007 Free Base; enasidenibum; 3T1SS4E7AG; CHEBI:145374; DTXSID801027942; RefChem:58279; L01XX59; DTXCID401513509; 107-597-8; AG-221; IDHIFA; AG-221 (Enasidenib); Enasidenib [INN]; AG 221

Frequently Asked Questions

What are the CAS number and molecular formula of Enasidenib?

CAS 1446502-11-9; molecular formula C19H17F6N7O; molecular weight — g/mol.

What other names is Enasidenib known by?

Enasidenib, 1446502-11-9, CC-90007 Free Base, enasidenibum, 3T1SS4E7AG, CHEBI:145374.

Is Enasidenib classified as hazardous?

Hazard statements reported: H360, H373, H413.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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