FELODIPINE

Description

FELODIPINE · CAS 72509-76-3 · C18H19Cl2NO4. UNII OL961R6O2C. Melting Point: 145; Melting Point: 145 °C; Solubility: 19.7.

Identification

CAS Registry Number	72509-76-3
PubChem CID	3333
Molecular formula	C18H19Cl2NO4
IUPAC name	5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	OL961R6O2C

Computed Descriptors

Molecular Weight	384.2
XLogP3	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	383.0691135
Monoisotopic Mass	383.0691135
Topological Polar Surface Area	64.6
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	145
Melting Point	145 °C
Solubility	19.7
Solubility	7.15e-03 g/L
LogP	3.86
LogP	3.8
LogP	3.65

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H302 (93.2%), H361 (22%), H373 (22%), H410 (15.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• Consumption (g per capita) in the USA (2002): 0.00278
• For the treatment of mild to moderate essential hypertension.
• Felodipine belongs to the dihydropyridine class of calcium channel blockers (CCBs) and is approved by the United States Food and Drug Administration (FDA) for the management and treatment of essential hypertension.
• Felodipine is a second generation calcium channel blocker and commonly used antihypertensive agent. Felodipine therapy has been associated with a low rate of serum enzyme elevations, but has not been convincingly linked to instances of clinically apparent, acute liver injury.

Synonyms

felodipine; 72509-76-3; Plendil; Flodil; Modip; Felodipina; Preslow; Felodipinum; DTXSID4023042; H 154/82; Felodipino; 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester; NSC-760343; OL961R6O2C; C08CA02; (+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Frequently Asked Questions

What are the CAS number and molecular formula of FELODIPINE?

CAS 72509-76-3; molecular formula C18H19Cl2NO4; molecular weight — g/mol.

What other names is FELODIPINE known by?

felodipine, 72509-76-3, Plendil, Flodil, Modip, Felodipina.

Is FELODIPINE classified as hazardous?

Hazard statements reported: H302, H361, H373, H410.

What are the key physical properties of FELODIPINE?

Melting Point: 145; Melting Point: 145 °C; Solubility: 19.7; Solubility: 7.15e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.