甲基亚硝基脲

Description

Methylnitrosourea · CAS 684-93-5 · C2H5N3O2. UNII W8KW4E3XSU. Melting Point: 123 °C; Solubility: In water, 1.443X10+4 mg/l at 24 °C; Vapor Pressure: 0.02 [mmHg].

Identification

CAS Registry Number	684-93-5
PubChem CID	12699
Molecular formula	C2H5N3O2
IUPAC name	1-methyl-1-nitrosourea
UNII (FDA)	W8KW4E3XSU

Computed Descriptors

Molecular Weight	103.08
XLogP3	0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	103.038176411
Monoisotopic Mass	103.038176411
Topological Polar Surface Area	75.8
Heavy Atom Count	7
Formal Charge	0

Physical & Chemical Properties

Melting Point	123 °C
Solubility	In water, 1.443X10+4 mg/l at 24 °C
Vapor Pressure	0.02 [mmHg]
LogP	log Kow = -0.03
LogP	-0.4

Physical description & handling notes

• N-nitroso-n-methylurea appears as pale yellow crystals or light yellow moist powder. (NTP, 1992)
• Colorless or yellow solid; [HSDB]
• Colorless or yellow plates from ethanol
• 255 °F (decomposes) (NTP, 1992)
• less than 1 mg/mL at 64 °F (NTP, 1992)
• Soluble in water

GHS Hazard Classification

Reported hazard statements	H228 (100%), H301 (100%), H350 (100%), H360 (100%), H317, H340

Documented Uses

• N-Nitroso-n-methylurea was used in the past for the laboratory synthesis of diazomethane, but it has been largely replaced by other reagents. N-Nitroso-n-methylurea has been studied in mutagenicity and genetics studies and for use as a cancer chemotherapy agent (alone or in combination with cyclophosphamide).
• Used as research chemical for its mutagenic effects on various plants; Formerly used to synthesize diazomethane in the laboratory; Not commercially produced in significant amounts; [HSDB]
• N-Nitroso-N-methylurea was once widely used to synthesize diazomethane in the laboratory; however, it has been replaced by other reagents for this use. N-Nitroso-N methylurea has been studied as a chemotherapeutic agent in cancer treatment, either alone or in combination with cyclophosphamide. Small quantities are used in research to study its mutagenic effects on plants.
• N-Nitroso-N-methylurea (NMU) was first prepared by Bruning in 1889 by the reaction of sodium nitrite with an aqueous solution of methylurea nitrate.
• (1977) NOT PRODUCED COMMERCIALLY IN USA
• (1979) NOT PRODUCED COMMERCIALLY IN USA

Synonyms

N-Methyl-N-nitrosourea; N-NITROSO-N-METHYLUREA; 684-93-5; Methylnitrosourea; Urea, N-methyl-N-nitroso-; 1-Nitroso-1-methylurea; Methylnitrosouree; N-Nitroso-N-methylcarbamide; Urea, 1-methyl-1-nitroso-; Methylnitroso-harnstoff; NSC 23909; SRI 859; N-Methyl-N-nitroso-harnstoff; N-Nitroso-N-methyl-harnstoff; SKI 24464; Carbamide, N-methyl-N-nitroso-

Frequently Asked Questions

What are the CAS number and molecular formula of Methylnitrosourea?

CAS 684-93-5; molecular formula C2H5N3O2; molecular weight — g/mol.

What other names is Methylnitrosourea known by?

N-Methyl-N-nitrosourea, N-NITROSO-N-METHYLUREA, 684-93-5, Methylnitrosourea, Urea, N-methyl-N-nitroso-, 1-Nitroso-1-methylurea.

Is Methylnitrosourea classified as hazardous?

Hazard statements reported: H228, H301, H350, H360, H317.

What are the key physical properties of Methylnitrosourea?

Melting Point: 123 °C; Solubility: In water, 1.443X10+4 mg/l at 24 °C; Vapor Pressure: 0.02 [mmHg]; LogP: log Kow = -0.03.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.