Nabumetone

Description

Nabumetone · CAS 42924-53-8 · C15H16O2. UNII LW0TIW155Z. Melting Point: 78-82; Melting Point: 80 °C; Solubility: 1.93e-03 g/L.

Identification

CAS Registry Number	42924-53-8
PubChem CID	4409
Molecular formula	C15H16O2
IUPAC name	4-(6-methoxynaphthalen-2-yl)butan-2-one
UNII (FDA)	LW0TIW155Z

Computed Descriptors

Molecular Weight	228.29
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	228.115029749
Monoisotopic Mass	228.115029749
Topological Polar Surface Area	26.3
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	78-82
Melting Point	80 °C
Solubility	1.93e-03 g/L
LogP	2400
LogP	3.1
LogP	3.45

Physical description & handling notes

• Solid
• Practically insoluble
• 148.38 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 142.47 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 152.86 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 152.13 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	14.3% (1 / 7)

GHS Hazard Classification

GHS notification summary	14.3% (1 / 7)
Reported hazard statements	H302 (42.9%), H315 (28.6%), H319 (14.3%), H332 (14.3%), H335 (14.3%), H361 (28.6%), H373 (14.3%), H400 (14.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >750
• Consumption (g per capita; approx.) in Germany (2009): 0.00916
• Consumption (g per capita) in the USA (2002): 0.273
• **Indicated** for: 1) Symptomatic relief in rheumatoid arthritis. 2) Symptomatic relief in osteoarthritis.
• Nabumetone is a long acting nonsteroidal antiinflammatory drug (NSAID) that is available by prescription only and is used in therapy of chronic arthritis. Nabumetone has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal

Synonyms

nabumetone; 42924-53-8; 4-(6-methoxynaphthalen-2-yl)butan-2-one; Relafen; Nabumetona; 4-(6-Methoxy-2-naphthyl)-2-butanone; nabumeton; Nabumetonum; BRL-14777; 4-(6-Methoxy-2-naphthalenyl)-2-butanone; DTXSID4045472; LW0TIW155Z; 2-Butanone, 4-(6-methoxy-2-naphthalenyl)-; NSC-758623; Nabumetone 750 mg; CHEBI:7443

Frequently Asked Questions

What are the CAS number and molecular formula of Nabumetone?

CAS 42924-53-8; molecular formula C15H16O2; molecular weight — g/mol.

What other names is Nabumetone known by?

nabumetone, 42924-53-8, 4-(6-methoxynaphthalen-2-yl)butan-2-one, Relafen, Nabumetona, 4-(6-Methoxy-2-naphthyl)-2-butanone.

Is Nabumetone classified as hazardous?

14.3% of GHS notifications report no hazard classification (1 of 7).

What are the key physical properties of Nabumetone?

Melting Point: 78-82; Melting Point: 80 °C; Solubility: 1.93e-03 g/L; LogP: 2400.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.