Naproxen

Description

Naproxen · CAS 22204-53-1 · C14H14O3. UNII 57Y76R9ATQ. Melting Point: 152°C; Melting Point: 155 °C; Melting Point: 153 °C.

Identification

CAS Registry Number	22204-53-1
PubChem CID	156391
Molecular formula	C14H14O3
IUPAC name	(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
UNII (FDA)	57Y76R9ATQ

Computed Descriptors

Molecular Weight	230.26
XLogP3	3.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	230.094294304
Monoisotopic Mass	230.094294304
Topological Polar Surface Area	46.5
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	152°C
Melting Point	155 °C
Melting Point	153 °C
Solubility	15.9
Solubility	In water, 15.9 mg/L at 25 °C
Solubility	0.0159 mg/mL at 25 °C
LogP	3.18
LogP	log Kow = 3.18
Ionization Efficiency	0.22
Ionization Efficiency	10.5

Physical description & handling notes

• Solid
• Crystals from acetone-hexane
• White to off-white crystalline powder
• White to creamy white, crystalline powder; soluble in water and sparingly soluble in alcohol. /Naproxen sodium/
• Practically odorless
• Crystals from acetone; mp: 244-246 °C; specific optical rotation: -11 deg at 25 °C/D (in methanol) /Naproxen sodium salt/

Regulatory Status

GHS notification summary	0.7% (1 / 139)

GHS Hazard Classification

GHS notification summary	0.7% (1 / 139)
Reported hazard statements	H301 (42.4%), H302 (57.6%), H315 (56.1%), H319 (55.4%), H335 (53.2%), H361 (49.6%)

Documented Uses

• Anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and sodium salt are used to treat rheumatoid arthritis and other musculoskeletal disorders, dysmmenorrhea, and acute gout.
• Non-steroidal anti-inflammatory drug
• THERAP CAT: Anti-inflammatory; analgesic; antipyretic
• THERAP CAT (VET): Anti-inflammatory
• For more Uses (Complete) data for NAPROXEN (6 total), please visit the HSDB record page.
• Use (kg) in Switzerland (2009): >1000

Synonyms

NAPROXEN; 22204-53-1; (S)-Naproxen; (+)-Naproxen; Equiproxen; Naprosyn; Naproxene; (S)-(+)-Naproxen; d-Naproxen; Nycopren; Naixan; Ec-Naprosyn; (+)-(S)-Naproxen; (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid; (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid; Laraflex

Frequently Asked Questions

What are the CAS number and molecular formula of Naproxen?

CAS 22204-53-1; molecular formula C14H14O3; molecular weight — g/mol.

What other names is Naproxen known by?

NAPROXEN, 22204-53-1, (S)-Naproxen, (+)-Naproxen, Equiproxen, Naprosyn.

Is Naproxen classified as hazardous?

0.7% of GHS notifications report no hazard classification (1 of 139).

What are the key physical properties of Naproxen?

Melting Point: 152°C; Melting Point: 155 °C; Melting Point: 153 °C; Solubility: 15.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.