雷鲁戈利克斯

Description

Relugolix · CAS 737789-87-6 · C29H27F2N7O5S. UNII P76B05O5V6. LogP: 1.69.

Identification

CAS Registry Number	737789-87-6
PubChem CID	10348973
Molecular formula	C29H27F2N7O5S
IUPAC name	1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
UNII (FDA)	P76B05O5V6

Computed Descriptors

Molecular Weight	623.6
XLogP3	3.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	9
Exact Mass	623.17624448
Monoisotopic Mass	623.17624448
Topological Polar Surface Area	157
Heavy Atom Count	44
Formal Charge	0

Physical & Chemical Properties

LogP	1.69

GHS Hazard Classification

Reported hazard statements	H360 (20%), H361 (60%), H371 (40%), H373 (20%), H411 (20%)

Documented Uses

• Relugolix is indicated for the treatment of adult patients with advanced prostate cancer. In a combination product with [estradiol] and [norethindrone], relugolix is indicated for the once-daily treatment for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.
• Relugolix is an orally administered, small molecule antagonist of gonadotropin releasing hormone (GnRH) that effectively blocks androgen production and is used to treat advanced prostate cancer. Relugolix therapy may be associated with a low rate of serum enzyme elevations during therapy, but has yet to be linked to instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Androgen Antagonists
• Relugolix is approved to treat men with:
• • Prostate cancer that is advanced.
• Take with or without food. Administration with food does not result in any clinically meaningful differences in pharmacokinetics.

Synonyms

Relugolix; 737789-87-6; TAK-385; Orgovyx; TAK 385; TAK385; P76B05O5V6; DTXSID40224167; MYFEMBREE COMPONENT RELUGOLIX; relugolixum; RefChem:57784; DTXCID40146658; MFCD25976856; C29H27F2N7O5S; CHEMBL1800159; Relugolix [USAN:INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Relugolix?

CAS 737789-87-6; molecular formula C29H27F2N7O5S; molecular weight — g/mol.

What other names is Relugolix known by?

Relugolix, 737789-87-6, TAK-385, Orgovyx, TAK 385, TAK385.

Is Relugolix classified as hazardous?

Hazard statements reported: H360, H361, H371, H373, H411.

What are the key physical properties of Relugolix?

LogP: 1.69.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.