卢非酰胺

Description

Rufinamide · CAS 106308-44-5 · C10H8F2N4O. UNII WFW942PR79. LogP: 0.835; LogP: 0.88.

Identification

CAS Registry Number	106308-44-5
PubChem CID	129228
Molecular formula	C10H8F2N4O
IUPAC name	1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide
UNII (FDA)	WFW942PR79

Computed Descriptors

Molecular Weight	238.19
XLogP3	0.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	238.06661722
Monoisotopic Mass	238.06661722
Topological Polar Surface Area	73.8
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

LogP	0.835
LogP	0.88

Physical description & handling notes

• Insoluble
• 148.6 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• At high concentrations will inhibit action of mGluR5 subtype receptors thus preventing the production of glutamate.

GHS Hazard Classification

Reported hazard statements	H336 (100%), H351 (40%), H361 (20%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Adjunct therapy for treatment of seizures associated with Lennox-Gastaut syndrome.
• Rufinamide is a triazole derivative drug structurally unrelated to any other anti-seizure drug (ASD). It was first developed in 2004 and later granted orphan drug status in October 2004. It was first marketed in Europe in January 2007. It was approved by the US FDA on November 14, 2008, for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS). Interestingly, it was the first anti-seizure medication to reach the US market with a pediatric indication prior to approval for adults.
• Rufinamide is a unique anticonvulsant that is used in combination with other agents as therapy of severe forms of seizure disorders. Rufinamide therapy is associated with a low rate of transient serum enzyme elevations and with rare instances of clinically apparent liver injury.
• Breast Feeding; Lactation; Anticonvulsants;

Synonyms

Rufinamide; 106308-44-5; Inovelon; Banzel; 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide; CGP-33101; Cgp 33101; RUF 331; RUF-331; 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide; Rufinamida; DTXSID1046506; E-2080; E2080; WFW942PR79; E 2080

Frequently Asked Questions

What are the CAS number and molecular formula of Rufinamide?

CAS 106308-44-5; molecular formula C10H8F2N4O; molecular weight — g/mol.

What other names is Rufinamide known by?

Rufinamide, 106308-44-5, Inovelon, Banzel, 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide, CGP-33101.

Is Rufinamide classified as hazardous?

Hazard statements reported: H336, H351, H361.

What are the key physical properties of Rufinamide?

LogP: 0.835; LogP: 0.88.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.