盐酸硫胺，维生素B1

Description

Thiamine Hydrochloride is identified by CAS 67-03-8, molecular formula C12H18Cl2N4OS and molecular weight 336.06 g/mol. UNII M572600E5P; ChEBI 49105; InChIKey DPJRMOMPQZCRJU-UHFFFAOYSA-M.

Identification

CAS Registry Number	67-03-8
PubChem CID	6202
Molecular formula	C12H18Cl2N4OS
Molecular weight	336.06 g/mol
IUPAC name	2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride
InChIKey	DPJRMOMPQZCRJU-UHFFFAOYSA-M
UNII (FDA)	M572600E5P
ChEBI ID	CHEBI:49105
FEMA number	3322
JECFA number	1030

Computed Descriptors

Molecular Weight	337.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	336.0578378
Monoisotopic Mass	336.0578378
Topological Polar Surface Area	104
Heavy Atom Count	20
Formal Charge	0
Complexity	268

Physical description & handling notes

• Solid with a mild thiazole odor; [Merck Index] White to light yellow crystalline powder; Hygroscopic; [Alfa Aesar MSDS]
• Small white to yellowish crystals or crystalline powder; slight characteristic odour reminescent of thiazole
• Soluble in water, propylene glycol; Insoluble in ether, benzene, hexane, chloroform
• Slightly soluble (in ethanol)

Regulatory Status

Regulatory & Food Contact	EU Flavoring substances FDA Substance added to food: FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent No safety concern at current levels of intake when used as a flavouring agent TRS 913-JECFA 59/65
GHS notification summary	66.2% (247 / 373)

GHS Hazard Classification

GHS notification summary	66.2% (247 / 373)
Reported hazard statements	H319 (33.2%)

Documented Uses

• Used as a human and veterinary vitamin (enzyme cofactor); [Merck Index] An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [ChemIDplus] Used as a flavoring agent and nutritional supplement for foods; [FDA] Permitted for use as an inert ingredient in
• For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis. Thiamine (hydrochloride) is a food additive used to add a brothy/meaty flavor to gravies or soups.
• Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
• Flavoring Agents -> JECFA Flavorings Index
• Information on 5 consumer products that contain Thiamine hydrochloride in the following categories is provided:
• Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride, hydrochloride (1:1:1): ACTIVE

Synonyms

THIAMINE HYDROCHLORIDE; 67-03-8; Thiamine HCL; Aneurine hydrochloride; Vitamin B1 hydrochloride; Clotiamina; Eskaphen; Betalin S; Thiamine chloride hydrochloride; Thiamine dichloride; Bevitine; Benerva; Thiamin chloride; Thiaminum hydrochloricum; Thiamin hydrochloride; Biamine

Frequently Asked Questions

What are the CAS number and molecular formula of Thiamine Hydrochloride?

CAS 67-03-8; molecular formula C12H18Cl2N4OS; molecular weight 336.06 g/mol.

What other names is Thiamine Hydrochloride known by?

THIAMINE HYDROCHLORIDE, 67-03-8, Thiamine HCL, Aneurine hydrochloride, Vitamin B1 hydrochloride, Clotiamina.

What is the regulatory status of Thiamine Hydrochloride?

Documented regulatory listings: EU Flavoring substances; FDA Substance added to food: FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT; Flavoring Agents.

Is Thiamine Hydrochloride classified as hazardous?

66.2% of GHS notifications report no hazard classification (247 of 373).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.