Description
Rebaudioside A · CAS 58543-16-1 · C44H70O23. UNII B3FUD0528F. Melting Point: 242 - 244 °C.
Identification
| CAS Registry Number | 58543-16-1 |
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| PubChem CID | 6918840 |
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| Molecular formula | C44H70O23 |
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| UNII (FDA) | B3FUD0528F |
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| FEMA number | 4601 |
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Computed Descriptors
| Molecular Weight | 967.0 |
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| XLogP3 | -2.8 |
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| Hydrogen Bond Donor Count | 14 |
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| Hydrogen Bond Acceptor Count | 23 |
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| Rotatable Bond Count | 13 |
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| Exact Mass | 966.43078848 |
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| Monoisotopic Mass | 966.43078848 |
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| Topological Polar Surface Area | 374 |
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| Heavy Atom Count | 67 |
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| Formal Charge | 0 |
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Physical & Chemical Properties
| Melting Point | 242 - 244 °C |
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Physical description & handling notes
- Solid
- The sweetness is tainted with a bitter and undesirable aftertaste. The time-intensity profile is characteristic of naturally occurring sweeteners: slow onset, but lingering. ... enzymatically glycosylated blend of stevioside and rebaudioside A, ... appears to impart a cleaner taste profile
- 299.48 Ų [M+H]+ [CCS Type: TW]
- Stevioside and rebaudioside A are diterpene glycosides. The aglycone moiety, steviol ... which is the principal metabolite, has been reported to be mutagenic. Wide use of stevia in Japan for > 30 years did not produce any known deleterious side effects.
Regulatory Status
| Regulatory & Food Contact | EU Flavoring substances
FDA Substance added to food: FLAVORING AGENT OR ADJUVANT
Flavoring Agents
SWEETENER: Food Additives
Can impart a licorice, creamy note; At low levels can alter the perception of sweetness, but does not impart s
Can impart a licorice, creamy note within flavor formulations; At low levels can alter the perception of sweet |
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| GHS notification summary | 100% (188 / 188) |
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GHS Hazard Classification
| GHS notification summary | 100% (188 / 188) |
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This chemical does not meet GHS hazard criteria for 100% (188 of 188) of all reports.
Reported as not meeting GHS hazard criteria by 188 of 188 companies. For more detailed information, please visit ECHA C&L website.
Documented Uses
- Naturally occurring potent sweetener
- Food Additives -> SWEETENER -> JECFA Functional Classes
- Stevioside can be isolated from the leaves of Stevia by extraction with water or water - ethanol mixtures. Crude Stevia extracts are more or less purified, e.g., by treatment with calcium or magnesium hydroxides or carbonates. Further purification by ion-exchangers, or absorption of undesired ingredients is possible. Stevioside can be obtained from the extracts by precipitation with methanol. ... Rebaudioside A is isolated from Stevia leaves in a similar way to stevioside. The ratio of rebaudioside A to stevioside
- Because no food additive petition has been presented to the FDA, stevioside and related materials cannot be used in the United States as food ingredients. An import alert against stevia was issued by the FDA in 1991. In 1995, however, the FDA revised this import alert to allow the importation and use of stevia as a dietary supplement, but not as a sweetener or an ingredient for foods.
- The dried leaves, the water extract of leaves, and the refined chemical ingredients, eg, Stevioside and Rebaudioside A ... (approximately 300X) /of Stevia rebaudiana Bertoni/ can all be used as sweetening agents. These are collectively referred to as stevia.
- Discovered in Paraguay and Brazil, /Stevia rebaudiana Bertoni/ was identified in the early 1970s as a plant of high economical value and transported to Japan for cultivation, where the commercialization of stevia leaves extract as a natural sweetener became a success. Today Stevia plant is cultivated primarily in China. ... In Japan, enzymatically glycosylated blend of stevioside and rebaudioside A, which appears to impart a cleaner taste profile, is also available commercially.
Synonyms
Rebaudioside A; 58543-16-1; Stevioside A3; Truvia; Rebaudioside-A; Rebiana; Rebaudiana a; Sweetener 4G-S; Reb-A; DTXSID8047898; Sooolite!-Pure; B3FUD0528F; Glycoside X; Reb-A 97; DTXCID50819922; INS NO.960A
Frequently Asked Questions
What are the CAS number and molecular formula of Rebaudioside A?
CAS 58543-16-1; molecular formula C44H70O23; molecular weight — g/mol.
What other names is Rebaudioside A known by?
Rebaudioside A, 58543-16-1, Stevioside A3, Truvia, Rebaudioside-A, Rebiana.
What is the regulatory status of Rebaudioside A?
Documented regulatory listings: EU Flavoring substances; FDA Substance added to food: FLAVORING AGENT OR ADJUVANT; Flavoring Agents.
Is Rebaudioside A classified as hazardous?
100% of GHS notifications report no hazard classification (188 of 188).
What are the key physical properties of Rebaudioside A?
Melting Point: 242 - 244 °C.
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.
