苯磺酸氨氯地平

Description

amlodipine besylate · CAS 111470-99-6 · C26H31ClN2O8S. UNII 864V2Q084H.

Identification

CAS Registry Number	111470-99-6
PubChem CID	60496
Molecular formula	C26H31ClN2O8S
IUPAC name	benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	864V2Q084H

Computed Descriptors

Molecular Weight	567.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Exact Mass	566.1489648
Monoisotopic Mass	566.1489648
Topological Polar Surface Area	163
Heavy Atom Count	38
Formal Charge	0
Complexity	830

Physical description & handling notes

• 187.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (96.6%), H315 (71%), H318 (25%), H319 (74.4%), H332 (30.7%), H335 (70.5%), H400 (20.5%), H410 (20.5%)

Documented Uses

• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
• Drugs used to cause dilation of the blood vessels.
• Calcium Channel Blocker [EPC]; Dihydropyridines [CS]; Cytochrome P450 3A Inhibitors [MoA]; Calcium Channel Antagonists [MoA]; Dihydropyridine Calcium Channel Blocker [EPC]

Synonyms

AMLODIPINE BESYLATE; 111470-99-6; Amlodipine besilate; Amlodipine benzenesulfonate; Antacal; Monopina; Norvas; Lodipressin; NORLIQVA; DTXSID2043909; Amlodipine (as besilate); NSC-758922; UK-48,340-26; 864V2Q084H; CHEBI:2669; DTXCID0023909

Frequently Asked Questions

What are the CAS number and molecular formula of amlodipine besylate?

CAS 111470-99-6; molecular formula C26H31ClN2O8S; molecular weight — g/mol.

What other names is amlodipine besylate known by?

AMLODIPINE BESYLATE, 111470-99-6, Amlodipine besilate, Amlodipine benzenesulfonate, Antacal, Monopina.

Is amlodipine besylate classified as hazardous?

Hazard statements reported: H302, H315, H318, H319, H332.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.