盐酸阿米洛利水合物

Description

amiloride hydrochloride hydrate · CAS 2016-88-8 · C6H8ClN7O.ClH. UNII 7M458Q65S3. Melting Point: 560.3 °F (NTP, 1992).

Identification

CAS Registry Number	2016-88-8
PubChem CID	16230
Molecular formula	C6H8ClN7O.ClH
IUPAC name	3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride
UNII (FDA)	7M458Q65S3

Computed Descriptors

Molecular Weight	266.09
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	265.0245633
Monoisotopic Mass	265.0245633
Topological Polar Surface Area	159
Heavy Atom Count	16
Formal Charge	0
Complexity	279

Physical & Chemical Properties

Melting Point	560.3 °F (NTP, 1992)

Physical description & handling notes

• Amiloride hydrochloride appears as crystalline solid or very light yellow powder. (NTP, 1992)
• less than 1 mg/mL at 67.1 °F (NTP, 1992)
• 145.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H301 (100%), H315 (63.3%), H319 (63.3%), H412 (62.5%)

Documented Uses

• Agents that promote the excretion of urine through their effects on kidney function.
• A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.
• A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS.

Synonyms

2016-88-8; Amiloride chloride; Amiloride hydrochloride anhydrous; CCRIS 5959; Amiloride Hydrochloride, Anhydrous; 7M458Q65S3; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; Anhydrous Amiloride Hydrochloride; RefChem:870453; Hydrochloride, Anhydrous Amiloride; 217-958-2; Amiloride HCl anhydrous; Amiloride hydrochloride hydrate; Amiloride (hydrochloride); 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride

Frequently Asked Questions

What are the CAS number and molecular formula of amiloride hydrochloride hydrate?

CAS 2016-88-8; molecular formula C6H8ClN7O.ClH; molecular weight — g/mol.

What other names is amiloride hydrochloride hydrate known by?

2016-88-8, Amiloride chloride, Amiloride hydrochloride anhydrous, CCRIS 5959, Amiloride Hydrochloride, Anhydrous, 7M458Q65S3.

Is amiloride hydrochloride hydrate classified as hazardous?

Hazard statements reported: H301, H315, H319, H412.

What are the key physical properties of amiloride hydrochloride hydrate?

Melting Point: 560.3 °F (NTP, 1992).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.