氨基鲁米特

Description

aminoglutethimide · CAS 125-84-8 · C13H16N2O2. UNII 0O54ZQ14I9. Melting Point: 223-225; Melting Point: 159-150 °C; Melting Point: 149 - 150 °C.

Identification

CAS Registry Number	125-84-8
PubChem CID	2145
Molecular formula	C13H16N2O2
IUPAC name	3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
UNII (FDA)	0O54ZQ14I9

Computed Descriptors

Molecular Weight	232.28
XLogP3	1.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	232.121177757
Monoisotopic Mass	232.121177757
Topological Polar Surface Area	72.2
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	223-225
Melting Point	159-150 °C
Melting Point	149 - 150 °C
Solubility	3.71e-01 g/L
LogP	1.3
LogP	0.6

Physical description & handling notes

• Solid
• Cyrstals from methanol or ethyl acetate
• Fine, white or creamy white crystalline powder
• Practically insoluble in water
• Freely soluble in most organic solvents; poorly soluble in ethyl acetate, 0.1N hydrochloric acid and absolute alcohol; readily soluble in acetone and 100% acetic acid. Practically insoluble in water.
• >34.8 [ug/mL] (The mean of the results at pH 7.4)

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%), H335 (97.6%)

Documented Uses

• THERAP CAT: Adrenocorticol supressant; antineoplastic
• Treatment of Cushing's syndrome
• For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
• Preparation: K. Hoffmann, E. Urech, US 2848455 (1958 to Ciba).
• Cytadren was marketed previously as an anticonvulsant but was withdrawn from marketing for that indication in 1966 because of the effects on the adrenal gland.
• Aminoglutethimide (Class: Other Substances, Added Date: 10-1998)

Synonyms

aminoglutethimide; 125-84-8; dl-Aminoglutethimide; Cytadren; Orimeten; p-Aminoglutethimide; Elipten; 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione; Aminoglutetimida; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione; 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-; Aminoglutethimidum; 2-(p-Aminophenyl)-2-ethylglutarimide; Ba-16038; Aminoglutetimide; 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine

Frequently Asked Questions

What are the CAS number and molecular formula of aminoglutethimide?

CAS 125-84-8; molecular formula C13H16N2O2; molecular weight — g/mol.

What other names is aminoglutethimide known by?

aminoglutethimide, 125-84-8, dl-Aminoglutethimide, Cytadren, Orimeten, p-Aminoglutethimide.

Is aminoglutethimide classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of aminoglutethimide?

Melting Point: 223-225; Melting Point: 159-150 °C; Melting Point: 149 - 150 °C; Solubility: 3.71e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.