盐酸阿洛司琼

盐酸阿洛司琼（CAS 122852-69-1）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• White to beige solid with a solubility of 61 mg/ml in water, 42 mg/ml in 0.1M hydrochloric acid, 0.3 mg/ml in pH 6 phosphate buffer, and <0.1 mg/ml in pH 8 phosphate buffer /Hydrochloride/
• Mol wt: 294.35. /Alosetron/
• The main ingredient in the drug Lotronex ... (tablets)

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Preparation: I.H. Coates et al., EP 306323; eidem, US 5360800 (1989, 1994 both to Glaxo)
• Alosetron, a selective 5-HT3-receptor antagonist, is indicated for the treatment of irritable bowel syndrome in female patients whose predominant symptom is diarrhea. /Salt not specified/
• ... Animal models have shown it to be active in anxiety, psychosis, cognitive impairment, emesis & drug withdrawal, though its application in humans has been almost entirely restricted to irritable bowel syndrome (IBS). ... Alosetron appears promising in the treatment of abdominal pain & discomfort & normalising of bowel function in patients with non-constipated IBS. It also improves quality of life, has a high degree of tolerability & has an excellent safety profile to date. /Salt not specified/
• Plasma concentrations of alosetron are 30 to 50% lower in men than in women given the same oral dose. In patients with irritable bowel syndrome, concentrations of alosetron are influenced by gender. Efficacy has not been established in men at any dose. /Salt not specified/
• /Alosetron/ should not be used in irritable bowel syndrome patients currently constipated or whose predominant bowel symptom in constipation because constipation is a frequent side effect of alosetron. /Salt not specified/
• ... Constipation is the most frequent adverse event, with a higher incidence of transient constipation in alosetron-treated patients, typically occurring in the first month of treatment. /Salt not specified/

它在各数据库里的别名

ALOSETRON HYDROCHLORIDE; 122852-69-1; Alosetron HCl; GR 68755c; Lotrpnex; DTXSID8044208; GR-68755C; 2F5R1A46YW; DTXCID6024208; 2,3,4,5-Tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one monohydrochloride; CHEBI:53783; RefChem:58091; 132414-02-9; Alosetron hydrochloride [USAN]; Alosetron (Hydrochloride); Alosetron Hydrochloride(1:X)

计算机算出的分子描述符

数据库摘要

Alosetron hydrochloride · CAS 122852-69-1 · C17H19ClN4O. UNII 2F5R1A46YW. 熔点: 288-291 °C.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。