安普那韦

安普那韦（CAS 161814-49-9）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Solid
• Henry's Law constant = 1.6X10-23 atm-cu m/mol @ 25 °C /Estimated/
• Hydroxyl radical reaction rate constant = 1.1X10-10 cu cm/molec sec @ 25 °C /Estimated/
• Oral: Capsules, liquid-filled, 50 mg, Agenerase (with propylene glycol 19 mg and vitamin E 36 units), GlaxoSmithKline; 150 mg, Agenerase (with propylene glycol and vitamin E 109 units), GlaxoSmithKline.Solution: 15 mg/ml, Agenerase (with propylene glycol 550 mg/ml, and vitamin E 46 units/ml), GlaxoSmithKline

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• For the treatment of HIV-1 infection in combination with other antiretroviral agents.
• Preparation: ... R.D. Tung et al, US 5585397 (1994, 1996 both to Vertex)
• Amprenavir is indicated in combination with other antiretroviral agents in the treatment of HIV-1 infection. /Included in US product labeling/
• Amprenavir is a human immunodeficiency virus (HIV)-protease inhibitor. The use of amprenavir for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in combination with other antiretrovirals is based on analyses of plasma HIV-RNA levels and CD4 cell counts in controlled studies of up to 24 weeks duration. Results from controlled trials evaluating the long-term suppression of HIV-RNA or disease progression with amprenavir have not yet been obtained.
• Patients being treated with amprenavir oral solution should be closely monitored for propylene glycol associated side effects including hemolysis, hyperosmolality, lactic acidosis, renal toxicity, seizures, stupor, and tachycardia.
• The pharmacokinetics of amprenavir do not differ between females and males or between Blacks and non-Blacks. However, amprenavir oral solution contains a large amount of propylene glycol and because Asians, Eskimos, Native Americans, and women have a decreased ability to metabolize this compound, they may have an increased risk of developing propylene glycol-associated side effects.

它在各数据库里的别名

amprenavir; 161814-49-9; Agenerase; VX-478; Prozei; 141W94; KVX-478; Vertex VX478; VX 478; 5S0W860XNR; CHEBI:40050; J05AE05; Tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate; KVX 478; DTXSID5046061; Amprenavirum

计算机算出的分子描述符

数据库摘要

AMPRENAVIR · CAS 161814-49-9 · C25H35N3O6S. UNII 5S0W860XNR. 溶解度: In water, 40 mg/l @ 25 °C; 溶解度: 4.91e-02 g/L; 蒸气压: 9.9X10-18 mm Hg @ 25 °C /Estimated/.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。