阿尔维螺旋霉素

阿尔维螺旋霉素（CAS 467214-20-6）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Soluble

这个物质在各数据库里的编号

数据库记载的用途

• Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia.
• Increasing concentration of the drug results in dose-proportional increase in the plasma concentration. At the maximum tolerated dose of 80mg/m^2, the plasma concentration exceeded 63nM (mean IC50 for 17-DMAG in the NCI 60 human tumor cell line panel) for less than 24 hours in all patients. The mean peak concentration (Cmax) reached 2680 nmol/L at this dose.
• Mainly renal and biliary elimination pathways. In a mice study, the excreted urine 24 hours post-dose recovered 10.6–14.8% of delivered dose unchanged.
• At the maximum tolerated dose of 80mg/m^2, the mean Vd value is 385 L.
• The mean clearance is 18.9 L/hr at the dose of 80mg/m^2.
• Alvespimycin demonstrates redox cycling catalyzed by purified human cytochrome P450 reductase (CYP3A4/3A5) to quinones and hydroquinones. It could also form glutathione conjugates at the 19-position on the quinone ring. However in vivo and in vitro studies suggest that weak metabolism of alvespimysin occurs in humans.

它在各数据库里的别名

alvespimycin; 467214-20-6; 17-DMAG; Alvespimycin [INN]; alvespimicina; alvespimycine; UNII-001L2FE0M3; 17-dimethylaminoethylamino-17-demethoxygeldanamycin; CHEBI:65324; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; NSC707545; NSC-707545; ALVESPIMYCIN [WHO-DD]; 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin

计算机算出的分子描述符

数据库摘要

Alvespimycin · CAS 467214-20-6 · C32H48N4O8. UNII 001L2FE0M3.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。