Description
Albiglutide · CAS 782500-75-8 · C148H223N39O46. UNII 5E7U48495E.
Identification
| CAS Registry Number | 782500-75-8 |
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| PubChem CID | 122173812 |
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| Molecular formula | C148H223N39O46 |
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| UNII (FDA) | 5E7U48495E |
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Computed Descriptors
| Molecular Weight | 3284.6 |
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| XLogP3 | -14 |
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| Hydrogen Bond Donor Count | 49 |
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| Hydrogen Bond Acceptor Count | 51 |
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| Rotatable Bond Count | 109 |
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| Exact Mass | 3283.6342956 |
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| Monoisotopic Mass | 3282.6309408 |
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| Topological Polar Surface Area | 1380 |
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| Heavy Atom Count | 233 |
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| Formal Charge | 0 |
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Physical description & handling notes
- White to yellow powder
- Chemical stability: Material is stable under normal conditions.
- Hazardous decomposition products: Irritating and/or toxic fumes and gases may be emitted upon the products decomposition.
- Solvent is clear, colorless; reconstituted solution is yellow
- Table: Albiglutide Preparations [Table#8276]
- Eperzan
Documented Uses
- Tanzeum is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. /Included in US product label/
- Albiglutide is produced in Saccharomyces cerevisiae using recombinant deoxyribonucleic acid (DNA) technology. The albiglutide drug substance manufacturing process consists of a series of steps which include cell culture, harvest, and purification stages.
- Preparation: C. A. Rosen, W. A. Haseltine, World Intellectual Property Organization patent 03059934; C. A. Rosen et al., USA patent 7141547 (2003, 2006 both to Human Genome Sciences).
- Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
- Albiglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to albiglutide therapy.
- /BOX WARNING/ Carcinogenicity of albiglutide could not be assessed in rodents, but other glucagon-like peptide-1 (GLP-1) receptor agonists have caused thyroid C-cell tumors in rodents at clinically relevant exposures. Human relevance of GLP-1 receptor agonist induced C-cell tumors in rodents has not been determined. It is unknown whether Tanzeum causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.
Synonyms
albiglutidum; Albiglutida; RefChem:141; A10BJ04; Albiglutide (genetical recombination); 5E7U48495E; 782500-75-8; Albiglutide; Eperzan; GSK-716155; GSK716155; Tanzeum; CHEBI:78425; SCHEMBL29349999; CHEBI:136045; HGB50075
Frequently Asked Questions
What are the CAS number and molecular formula of Albiglutide?
CAS 782500-75-8; molecular formula C148H223N39O46; molecular weight — g/mol.
What other names is Albiglutide known by?
albiglutidum, Albiglutida, RefChem:141, A10BJ04, Albiglutide (genetical recombination), 5E7U48495E.
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.
