阿瓦普替尼

阿瓦普替尼（CAS 1703793-34-3）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Avapritinib is a selective kinase inhibitor that negatively modulates the action of cell transporters to resensitize them to other chemotherapies. It has a long duration of action as it is given once daily. Patients should be counselled regarding the risk of intracranial hemorrhage, CNS effects, and embryo-fetal toxicity.

这个物质在各数据库里的编号

数据库记载的用途

• Avapritinib is a tyrosine kinase receptor inhibitor that targets mutant forms of several genes (KIT, PDGFRA) involved in gastrointestinal stromal tumors which are often found in refractory cases. Serum aminotransferase elevations arise in a small proportion of patients treated with the highest doses of avapritinib, but episodes of clinically apparent liver injury have not been reported with its use.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Avapritinib is approved to treat adults with:
• • Gastrointestinal stromal tumor (GIST) that cannot be removed by surgery or has metastasized (spread to other parts of the body) and has certain mutations in the PDGFRA gene.
• • Systemic mastocytosis that is advanced, including the following types:
• • Aggressive systemic mastocytosis.

它在各数据库里的别名

Avapritinib; 1703793-34-3; BLU-285; Ayvakit; 513P80B4YJ; C-366; 70C366; DTXSID301027935; X720776; X-720776; avapritinibum; RefChem:56916; DTXCID501513502; CS3007; PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285; MFCD31544325

计算机算出的分子描述符

数据库摘要

Avapritinib · CAS 1703793-34-3 · C26H27FN10. UNII 513P80B4YJ.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。