阿拉地平

阿拉地平（CAS 86780-90-7）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Insoluble

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Aranidipine has been used for many years to treat angina pectoris and hypertension.
• After administration, aranidipine is rapidly absorbed from the gastrointestinal tract. After absorption, the AUC and Cmax increased linearly in a dose-dependent manner, the Cmax was attained in approximate 3.8-4.8 hours for aranidipine and 4.8-6 hours for the metabolite M-1. The bioavailability of aranidipine in rat, dog, and monkey was about 48%, 41% and 3% respectively.
• Unchanged aranidipine is found in plasma but not in the urine after 1 hour of administration. Just a small amount of drug was found in the bile. These results indicate that the excretion profile of aranidipine is mainly driven by metabolism and not by excretion. When including the metabolites, 52-56% of the original dose is disposed in the urine, 34-45% in feces and 3-4% in expired air. The excretion in the bile was 59% of the administered dose and 63% of this portion is reabsorbed.
• The binding ratio of plasma proteins of aranidipine varies from 84-95%. This ratio of the drug is similar to the unchanged form and for the M-1 metabolite. Most of the binding happens towards serum albumin and a lower amount corresponds to the alpha1-acid glycoprotein.
• Eight metabolites of aranidipine were found after oral administration. These metabolites were brought by a reduction of the ketone group, oxidation of dihydropyridine ring and de-esterification at the C-3 position.
• The elimination half-life of aranidipine and the M-1 metabolite are 1.1-1.2 hour and 2.7-3.5 hour respectively.

它在各数据库里的别名

aranidipine; 86780-90-7; Sapresta; Mpc-1304; MPC1304; DTXSID9048649; Aranidipino; 4Y7UR6X2PO; 3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-METHYL 5-(2-OXOPROPYL) 2,6-DIMETHYL-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE; DTXCID6028575; aranidipinum; RefChem:559905; methyl 2-oxopropyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid; Aranidipine [INN]; (+-)-Acetonyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate

计算机算出的分子描述符

数据库摘要

Aranidipine · CAS 86780-90-7 · C19H20N2O7. UNII 4Y7UR6X2PO. 熔点: 149-150ºC.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。