盐酸安非拉酮

Description

Amfepramone HCL · CAS 134-80-5 · C13H19NO. UNII Q94YYU22B8. Melting Point: 168; Solubility: 1.22e+00 g/L; LogP: 2.8.

Identification

CAS Registry Number	134-80-5
PubChem CID	7029
Molecular formula	C13H19NO
IUPAC name	2-(diethylamino)-1-phenylpropan-1-one
UNII (FDA)	Q94YYU22B8

Computed Descriptors

Molecular Weight	205.30
XLogP3	2.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	205.146664230
Monoisotopic Mass	205.146664230
Topological Polar Surface Area	20.3
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

Melting Point	168
Solubility	1.22e+00 g/L
LogP	2.8
LogP	1.5

Physical description & handling notes

• Solid
• White or creamy white, small crystals or crystalline powder; characteristic, mildly aromatic odor; 1 g sol in: about 0.6 mL water, about 0.6 ml chloroform, 1 ml absolute methanol, 1 ml alcohol; practically insoluble in ether /Diethylpropion hydrochloride/
• Stable in dry air /Diethylpropion hydrochloride/
• When heated to decomp it emits very toxic fumes of /hydrogen chloride and nitrogen oxides./ /Diethylpropion hydrochloride/
• 146.9 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated]
• 148 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Documented Uses

• ... Reduce appetite and lower food intake ... /Former/
• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Used as an antidepressant. [Wikipedia]. Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.
• Preperation: Schutte, US 3001910 (1961 to Temmler-Werke)
• Propiophenone is brominated with bromine to form 2-bromopropiophenone which is then condensed with diethylamine to yield diethylpropion (base). Purified base is dissolved in suitable solvent & treated with hydrogen chloride to form salt. /Hydrochloride/

Synonyms

DIETHYLPROPION; Amfepramone; Diethylpropione; Amfepramon; Amphepramone; Nopropiophenone; Adiposon; Amphepramon; Frekentine; Danylen; Magrene; Tylinal; Diethylcathinone; 90-84-6; alpha-Benzoyltriethylamine; Amfepramonum

Frequently Asked Questions

What are the CAS number and molecular formula of Amfepramone HCL?

CAS 134-80-5; molecular formula C13H19NO; molecular weight — g/mol.

What other names is Amfepramone HCL known by?

DIETHYLPROPION, Amfepramone, Diethylpropione, Amfepramon, Amphepramone, Nopropiophenone.

What are the key physical properties of Amfepramone HCL?

Melting Point: 168; Solubility: 1.22e+00 g/L; LogP: 2.8; LogP: 1.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.