巴瑞克替尼

Description

Baricitinib · CAS 1187594-09-7 · C16H17N7O2S. UNII ISP4442I3Y. Boiling Point: 707.2.

Identification

CAS Registry Number	1187594-09-7
PubChem CID	44205240
Molecular formula	C16H17N7O2S
IUPAC name	2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
UNII (FDA)	ISP4442I3Y

Computed Descriptors

Molecular Weight	371.4
XLogP3	-0.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	371.11644398
Monoisotopic Mass	371.11644398
Topological Polar Surface Area	129
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Boiling Point	707.2

GHS Hazard Classification

Reported hazard statements	H302 (50%), H335 (16.7%), H360 (66.7%), H372 (16.7%), H373 (66.7%), H411 (66.7%)

Documented Uses

• Baricitinib is a disease-modifying antirheumatic drug (DMARD) indicated for rheumatoid arthritis when conventional DMARDs prove inadequate.
• Baricitinib is an orally available small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis, severe alopecia areata, and, in combination with remdesivir, severe COVID-19 in hospitalized patients requiring supplementary oxygen. Baricitinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy but has yet to be linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antirheumatic Agents; Enzyme Inhibitors; Janus Kinase Inhibitors; JAK Inhibitors; Signal Transduction Inhibitors; Protein Kinase Inhibitors
• Baricitinib (Class: Other Substances, Added Date: 03-2022)
• Take with or without food. A high-fat meal can decrease the mean AUC and Cmax of baricitinib and delay Tmax, but not to a clinically singificant extent.
• Established Pharmacologic Class [EPC] - Janus Kinase Inhibitor

Synonyms

Baricitinib; 1187594-09-7; olumiant; LY3009104; INCB028050; INCB 028050; INCB-028050; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; LY-3009104; LY 3009104; ISP4442I3Y; DTXCID5074719; CHEBI:95341; DTXSID30152228; L04AA37; 3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-

Frequently Asked Questions

What are the CAS number and molecular formula of Baricitinib?

CAS 1187594-09-7; molecular formula C16H17N7O2S; molecular weight — g/mol.

What other names is Baricitinib known by?

Baricitinib, 1187594-09-7, olumiant, LY3009104, INCB028050, INCB 028050.

Is Baricitinib classified as hazardous?

Hazard statements reported: H302, H335, H360, H372, H373.

What are the key physical properties of Baricitinib?

Boiling Point: 707.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.