布加替尼

Description

Brigatinib · CAS 1197953-54-0 · C29H39ClN7O2P. UNII HYW8DB273J. LogP: 5.17.

Identification

CAS Registry Number	1197953-54-0
PubChem CID	68165256
Molecular formula	C29H39ClN7O2P
IUPAC name	5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine
UNII (FDA)	HYW8DB273J

Computed Descriptors

Molecular Weight	584.1
XLogP3	4.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	8
Exact Mass	583.2591382
Monoisotopic Mass	583.2591382
Topological Polar Surface Area	85.9
Heavy Atom Count	40
Formal Charge	0

Physical & Chemical Properties

LogP	5.17

Physical description & handling notes

• Insoluble

GHS Hazard Classification

Reported hazard statements	H301 (100%), H361 (100%), H372 (100%), H410 (100%)

Documented Uses

• Brigatinib is a tyrosine kinase receptor inhibitor and antineoplastic agent used in the therapy of selected forms of advanced non-small cell lung cancer. Brigatinib is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy but has yet to be linked to instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors;
• Brigatinib is approved to treat:
• • Non-small cell lung cancer that is ALK positive and has metastasized (spread to other parts of the body). It is used in adults.
• Brigatinib is also being studied in the treatment of other types of cancer.
• Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of brigatinib.

Synonyms

Brigatinib; 1197953-54-0; ALUNBRIG; AP-26113; HYW8DB273J; DTXSID501027929; brigatinibum; RefChem:56949; L01XE43; DTXCID501513495; AP 26113; Brigatinib [USAN]; Brigatinib (AP-26113); MFCD29472221; Brigatinib (AP26113); NCGC00483924-01

Frequently Asked Questions

What are the CAS number and molecular formula of Brigatinib?

CAS 1197953-54-0; molecular formula C29H39ClN7O2P; molecular weight — g/mol.

What other names is Brigatinib known by?

Brigatinib, 1197953-54-0, ALUNBRIG, AP-26113, HYW8DB273J, DTXSID501027929.

Is Brigatinib classified as hazardous?

Hazard statements reported: H301, H361, H372, H410.

What are the key physical properties of Brigatinib?

LogP: 5.17.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.