布南色林

Description

Blonanserin · CAS 132810-10-7 · C23H30FN3. UNII AQ316B4F8C. LogP: 5.266.

Identification

CAS Registry Number	132810-10-7
PubChem CID	125564
Molecular formula	C23H30FN3
IUPAC name	2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
UNII (FDA)	AQ316B4F8C

Computed Descriptors

Molecular Weight	367.5
XLogP3	5.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	367.24237613
Monoisotopic Mass	367.24237613
Topological Polar Surface Area	19.4
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

LogP	5.266

Physical description & handling notes

• Blonanserin antagonizes dopamine and serotonin receptors to reduce symptoms of schizophrenia.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H413 (97.6%)

Documented Uses

• Used for the treatment of schizophrenia.
• Blonanserin has a Tmax of 1.5 h and a bioavailablity of 55%. Tmax has been observed to be prolonged and relative bioavailability increased when administered with food.
• 57% of blonanserin is excreted in the urine and 30% in the feces. Only 5% of the drug in the feces is the parent drug with no parent drug excreted through the urine.
• Blonanserin has a Vc of 9500 L and a Vt of 8560 L for a total Vd of 18060 L.
• Blonanserin has a clearance of 1230 L/h.
• Blonanserin is over 99.7% bound to plasma proteins . Serum albumin is the primary binder.

Synonyms

Blonanserin; 132810-10-7; AD-5423; 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine; Blonanserina; Blonanserine; DTXSID7048790; AQ316B4F8C; DSP-5423; 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta(b)pyridine; 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine; CYCLOOCTA[B]PYRIDINE, 2-(4-ETHYL-1-PIPERAZINYL)-4-(4-FLUOROPHENYL)-5,6,7,8,9,10-HEXAHYDRO-; DTXCID3028716; Cycloocta(b)pyridine, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-; 2-(4-ETHYLPIPERAZIN-1-YL)-4-(4-FLUOROPHENYL)-5,6,7,8,9,10-HEXAHYDROCYCLOOCTA(B)PYRIDINE; AD5423

Frequently Asked Questions

What are the CAS number and molecular formula of Blonanserin?

CAS 132810-10-7; molecular formula C23H30FN3; molecular weight — g/mol.

What other names is Blonanserin known by?

Blonanserin, 132810-10-7, AD-5423, 2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine, Blonanserina, Blonanserine.

Is Blonanserin classified as hazardous?

Hazard statements reported: H302, H413.

What are the key physical properties of Blonanserin?

LogP: 5.266.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.