波吲洛尔

Description

Bopindolol · CAS 62658-63-3 · C23H28N2O3. UNII KT304VZO57. Melting Point: 152 - 153 °C; Solubility: 3.3.

Identification

CAS Registry Number	62658-63-3
PubChem CID	44112
Molecular formula	C23H28N2O3
IUPAC name	[1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl] benzoate
UNII (FDA)	KT304VZO57

Computed Descriptors

Molecular Weight	380.5
XLogP3	4.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	380.20999276
Monoisotopic Mass	380.20999276
Topological Polar Surface Area	63.4
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

Melting Point	152 - 153 °C
Solubility	3.3

Physical description & handling notes

• Solid
• 152–153 [malonate salt]

Documented Uses

• For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
• Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
• C07AA - Beta blocking agents, non-selective
• QC07AA - Beta blocking agents, non-selective
• Bopindolol (as pindolol) non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, Pindolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.

Synonyms

BOPINDOLOL; 62658-63-3; (+-)-Bopindolol; Bopindololum; DTXSID6022684; KT304VZO57; DTXCID402684; 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((2-methyl-1H-indol-4-yl)oxy)-, benzoate (ester), (+-)-; RefChem:569816; CHEBI:76749; C07AA17; 1-(tert-butylamino)-3-((2-methylindo)-4-yl)-2-propanol benzoate; rac Bopindolol; Bopindolol [INN]; 1-(tert-Butylamino)-3-((2-methyl-1H-indol-4-yl)oxy)propan-2-yl benzoate; [1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl] benzoate

Frequently Asked Questions

What are the CAS number and molecular formula of Bopindolol?

CAS 62658-63-3; molecular formula C23H28N2O3; molecular weight — g/mol.

What other names is Bopindolol known by?

BOPINDOLOL, 62658-63-3, (+-)-Bopindolol, Bopindololum, DTXSID6022684, KT304VZO57.

What are the key physical properties of Bopindolol?

Melting Point: 152 - 153 °C; Solubility: 3.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.