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Description

Desogestrel · CAS 54024-22-5 · C22H30O. UNII 81K9V7M3A3. Boiling Point: 428ºC; Melting Point: 109-110ºC; Melting Point: 109-110 °C.

Identification

CAS Registry Number	54024-22-5
PubChem CID	40973
Molecular formula	C22H30O
IUPAC name	(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
UNII (FDA)	81K9V7M3A3

Computed Descriptors

Molecular Weight	310.5
XLogP3	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	310.229665576
Monoisotopic Mass	310.229665576
Topological Polar Surface Area	20.2
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Boiling Point	428ºC
Melting Point	109-110ºC
Melting Point	109-110 °C
Melting Point	109.5 °C
Solubility	<1 mg/ml
Solubility	3.01e-03 g/L
LogP	5.65
Dissociation Constants	13.04

Physical description & handling notes

• Solid
• Crystals
• Slightly soluble in ethanol and ethyl acetate; sparingly soluble in n-hexane.
• Specific optical rotation = +55 deg at 20 °C/D (chloroform)
• When heated to decomposition it emits acrid smoke and fumes.
• Oral: Tablets: 0.15 mg/0.03 mg (desogestrel and ethinyl estradiol), Apri (Barr Laboratories Inc).

GHS Hazard Classification

Reported hazard statements	H360 (10.8%), H372 (27.7%), H400 (60%), H410 (89.2%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• Consumption (g per capita) in the USA (2002): 5.03e-05
• /Desogestrel/ is produced by adding a solution of 11,11-methylene-18-methyl-delta4-estren-17-one in tetrahydrofuran to potassium acetylide solution in tetrahydrofuran and acidified.
• Reported impurities include: 13-ethyl-16-[13-ethyl-17beta-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-16-ylidene]-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17beta-ol, 13-ethyl-11-methylene-18,19-dinor-5alpha,17alpha-pregn-3-en-20-yn-17-ol (desogestrel D3-isomer) and 11-methylene-19-nor-17alpha-pregn-4-en-20-yn-17-ol; 13-ethyl-11-methylenegon-4-en-17-one.
• ...manufactured or formulated in Argentina, Australia, Belgium, Brazil, Canada, France, Germany, India, Mexico, the Netherlands, South Africa, Spain, Switzerland, the United Kingdom, and the United States.

Synonyms

DESOGESTREL; 54024-22-5; Cerazette; Desogestrelum; Org-2969; ORG 2969; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; DTXSID6022898; 81K9V7M3A3; CHEBI:4453; DTXCID702898; VOLNEA COMPONENT DESOGESTREL; BEKYREE COMPONENT DESOGESTREL; ENSKYCE COMPONENT DESOGESTREL; PIMTREA COMPONENT DESOGESTREL; VIORELE COMPONENT DESOGESTREL

Frequently Asked Questions

What are the CAS number and molecular formula of Desogestrel?

CAS 54024-22-5; molecular formula C22H30O; molecular weight — g/mol.

What other names is Desogestrel known by?

DESOGESTREL, 54024-22-5, Cerazette, Desogestrelum, Org-2969, ORG 2969.

Is Desogestrel classified as hazardous?

Hazard statements reported: H360, H372, H400, H410.

What are the key physical properties of Desogestrel?

Boiling Point: 428ºC; Melting Point: 109-110ºC; Melting Point: 109-110 °C; Melting Point: 109.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.