道诺霉素

Description

Daunomycin · CAS 20830-81-3 · C27H29NO10. UNII ZS7284E0ZP. Boiling Point: 190; Boiling Point: 190 °C, decomposes; Melting Point: 208-209 °C.

Identification

CAS Registry Number	20830-81-3
PubChem CID	30323
Molecular formula	C27H29NO10
IUPAC name	(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
UNII (FDA)	ZS7284E0ZP

Computed Descriptors

Molecular Weight	527.5
XLogP3	1.8
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	4
Exact Mass	527.17914612
Monoisotopic Mass	527.17914612
Topological Polar Surface Area	186
Heavy Atom Count	38
Formal Charge	0

Physical & Chemical Properties

Boiling Point	190
Boiling Point	190 °C, decomposes
Melting Point	208-209 °C
Melting Point	208 - 209 °C
Solubility	30000
Solubility	In water, 3.0X10+4 mg/L at 25 °C
Solubility	6.27e-01 g/L
Vapor Pressure	9.4X10-15 mm Hg at 25 °C
LogP	1.83
LogP	log Kow = 1.83

Physical description & handling notes

• Anthracycline antibiotic. An anticancer agent.
• Thin, red needles; [HSDB]
• Solid
• Reddish needles
• Thin, red needles
• Soluble in methyl alcohol, insoluble in chloroform and benzene.

GHS Hazard Classification

Reported hazard statements	H301 (100%), H341 (100%), H351 (100%), H361 (100%)

Documented Uses

• An anti-mitotic agent used in cancer chemotherapy; [HSDB]
• Antimitotic agent in cancer chemotherapy (non-USA use).
• Therapeutic Category: Antineoplastic
• For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
• Isolated from fermentation broths of Streptomyces peucetius.
• Daunorubicin is obtained from cultures of Streptomyces caeruleorubidus and Streptomyces peucetius, which occur in soil.

Synonyms

daunorubicin; Daunomycin; 20830-81-3; Acetyladriamycin; Leukaemomycin C; Daunorubicine; Rubidomycin; (+)-Daunomycin; Rubomycin C; Daunarubicinum; Daunorrubicina; Daunamycin; Daunorubicinum; Cerubidin; RP 13057; FI6339

Frequently Asked Questions

What are the CAS number and molecular formula of Daunomycin?

CAS 20830-81-3; molecular formula C27H29NO10; molecular weight — g/mol.

What other names is Daunomycin known by?

daunorubicin, Daunomycin, 20830-81-3, Acetyladriamycin, Leukaemomycin C, Daunorubicine.

Is Daunomycin classified as hazardous?

Hazard statements reported: H301, H341, H351, H361.

What are the key physical properties of Daunomycin?

Boiling Point: 190; Boiling Point: 190 °C, decomposes; Melting Point: 208-209 °C; Melting Point: 208 - 209 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.