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地昔帕明

CAS 50-47-5C18H22N2MW 266.4

地昔帕明（CAS 50-47-5）：分子式 C18H22N2、分子量 266.4；类别 医药中间体及原料药。

产品描述

地昔帕明（CAS 50-47-5）是一种医药中间体及原料药原料。其分子式 C18H22N2 由 18 个碳、22 个氢、2 个氮 组成。 分子量约为 266.4。公开物性数据显示其熔点约 214-218 °C、沸点约 172-174 °C @ 0.02 MM HG、LogP 约 4.9。作为化工品采购代理与分销渠道，我们可在国内及跨境渠道为地昔帕明寻源比价，并安排小批量试样与批次采购；下单前提供完整 COA、质检报告与合规文件，验收以批次 COA 为准。

规格参数

CAS号50-47-5
分子式C18H22N2
分子量266.4
熔点214-218 °C
沸点172-174 °C @ 0.02 MM HG
LogP4.9
应用领域Antidepressant、For relief of symptoms in various depressive syndromes、especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain、as a second line agent for the management of anxiety disorders (e.g. panic disorder、generalized anxiety disorder)、and as a second or third line agent in the ADHD management
类别医药中间体及原料药

用途与场景

登记用途：Antidepressant、For relief of symptoms in various depressive syndromes、especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain、as a second line agent for the management of anxiety disorders (e.g. panic disorder、generalized anxiety disorder)、and as a second or third line agent in the ADHD management。

采购档案

这个产品是什么

地昔帕明 是一种医药中间体或原料药类化合物，登记 CAS 号为 50-47-5，分子式 C18H22N2（分子量 266.4），归属于医药中间体及原料药大类化工原料。

识别信息

登记 CAS 号：50-47-5

其分子式 C18H22N2 由 18 个碳、22 个氢、2 个氮 组成。

别名/同义词：地昔帕明 · desipramine

所属分类：医药中间体及原料药

常见问题

地昔帕明 的 CAS 号是多少？

地昔帕明 的 CAS 登记号为 50-47-5。

地昔帕明 的分子式与分子量是多少？

分子式 C18H22N2，分子量 266.4。

地昔帕明 还有哪些别名？

别名/同义词：地昔帕明、desipramine。

地昔帕明 的登记用途是什么？

登记用途：Antidepressant、For relief of symptoms in various depressive syndromes、especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain、as a second line agent for the management of anxiety disorders (e.g. panic disorder、generalized anxiety disorder)、and as a second or third line agent in the ADHD management。

地昔帕明 属于哪个分类？

所属分类：医药中间体及原料药。

如何在 591daili.cn 采购 地昔帕明？

请在联系页面提交产品名称、CAS 号与数量，我们作为采购代理在国内及跨境渠道为您寻源比价，安排试样与批次采购，下单前提供 COA 与合规文件。

包装与单证

包装按订单确认，从实验室小包装到吨袋大货，随订单安排而非在页面上写死。每批随货附 COA 分析证书，可另提供 MSDS；若终端用途带有法规限度（食品接触、药品或化妆品），请在询价时说明执行标准，等级按该标准确定。

PubChem 公开数据

地昔帕明（CAS 50-47-5）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

Reported hazard statementsH302 (66.7%), H336 (66.7%), H370 (66.7%), H400 (33.3%)

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H336 (66.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

物理形态与操作说明

  • Solid
  • WHITE CRYSTALLINE POWDER; ODORLESS; BITTER TASTE; MELTS WITHIN 5 DEG RANGE BETWEEN 208-218 °C; 1 G IN CA 4 ML CHLOROFORM, 20 ML WATER, 20 ML ALC; FREELY SOL IN METHANOL; INSOL IN ETHER /HCL/
  • UNSTABLE AFTER LONG EXPOSURE TO LIGHT, HEAT, & AIR /HYDROGEN CHLORIDE/
  • When heated to decomposition it emits toxic fumes of nitroxides.
  • 163.5 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: Antidepressants]
  • 160.93 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

公开数据库收录的理化数据

沸点172-174 °C @ 0.02 MM HG
熔点214-218 °C
熔点214 - 218 °C
溶解度58.6
溶解度In water, 58.6 mg/l @ 24 °C.
溶解度3.96e-02 g/L
LogP4.9
LogPlog Kow = 4.90
LogP3.7
LogP4.0

这个物质在各数据库里的编号

CAS Registry Number50-47-5
PubChem CID2995
分子式C18H22N2
IUPAC 名称3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
UNII（FDA）TG537D343B

数据库记载的用途

  • For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.
  • FREE BASE & HYDROCHLORIDE: BRITISH PATENT 908,788 (1962 TO GEIGY)
  • PREPN OF HYDROCHLORIDE: BELGIAN PATENT 614,616, CA 58 11338C (1963), (1962 TO GEIGY)
  • Desipramine is a tricyclic antidepressant (TCA) classified as a secondary amine (see Image. Desipramine Skeletal Formula). Compared to tertiary amines such as amitriptyline, desipramine is associated with fewer anticholinergic adverse effects.
  • Desipramine is an oral tricyclic antidepressant that widely used in the therapy of depression. Desipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
  • Breast Feeding; Lactation; Milk, Human; Antidepressive Agents; Antidepressive Agents, Tricyclic

它在各数据库里的别名

desipramine; Norimipramine; 50-47-5; Desmethylimipramine; Monodemethylimipramine; Desipramin; Demethylimipramine; Desimipramine; Dimethylimipramine; Dezipramine; Desipramina; Methylaminopropyliminodibenzyl; Imipramine, demethyl-; desipraminum; Desimpramine; 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE

计算机算出的分子描述符

分子量266.4
XLogP34.9
氢键供体数1
氢键受体数2
可旋转键数4
精确质量266.178298710
单同位素质量266.178298710
拓扑极性表面积15.3
重原子数20
形式电荷0

数据库摘要

desipramine · CAS 50-47-5 · C18H22N2. UNII TG537D343B. 沸点: 172-174 °C @ 0.02 MM HG; 熔点: 214-218 °C; 熔点: 214 - 218 °C.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。

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