达芦那韦

Name: 达芦那韦
Brand: 济南圣和化工有限公司

CAS 206361-99-1C27H37N3O7SMW 547.7

达芦那韦，CAS 登记号 206361-99-1，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于医药中间体及原料药。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号206361-99-1

分子式C27H37N3O7S

分子量547.7

熔点74-76

LogP1.89

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域医药中间体及原料药

类别医药中间体及原料药

用途与场景

医药中间体及原料药

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

文件与支持

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常见问题

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本页已列出达芦那韦的 CAS 号：206361-99-1，可与随货 COA 核对。

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达芦那韦一般用在什么产品里？

主要涉及医药中间体及原料药。

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PubChem 公开数据

Description

Darunavir · CAS 206361-99-1 · C27H37N3O7S. UNII YO603Y8113. Melting Point: 74-76; Melting Point: 74 °C (decomposes); Solubility: 6.68e-02 g/L.

Identification

CAS Registry Number	206361-99-1
PubChem CID	213039
Molecular formula	C27H37N3O7S
IUPAC name	[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
UNII (FDA)	YO603Y8113

Computed Descriptors

Molecular Weight	547.7
XLogP3	2.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	12
Exact Mass	547.23522170
Monoisotopic Mass	547.23522170
Topological Polar Surface Area	149
Heavy Atom Count	38
Formal Charge	0

Physical & Chemical Properties

Melting Point	74-76
Melting Point	74 °C (decomposes)
Solubility	6.68e-02 g/L
LogP	1.89
LogP	1.8

Physical description & handling notes

Solid
White, amorphous solid
Approximately 0.15 mg/mL at
11.43±0.46(Predicted)
Darunavir is an inhibitor of the human immunodeficiency virus (HIV) protease, which prevents HIV viral replication. When administered with ritonavir in combination antiretroviral therapy, darunavir significantly decreases viral load and increases CD4 cell counts, decreasing the morbidity and mortality of HIV infection.
Oral: Tablets, film-coated 300 mg (of darunavir) Prezista (Tibotec); 600 mg (of darunavir) Prezista (Tibotec).

GHS Hazard Classification

Reported hazard statements	H315 (100%), H317 (100%), H319 (100%), H335 (100%)

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Documented Uses

Inhibitor of the HIV-1 protease
THERAPEUTIC CATEGORY: Antiviral
Use (kg; approx.) in Germany (2009): >750
Consumption (g per capita; approx.) in Germany (2009): 0.00916
Darunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) in children age 3 or above and adults with HIV-1 infection.
Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Protease Inhibitors

Synonyms

Darunavir; 206361-99-1; TMC114; TMC-114; UIC-94017; Darunavirum; TMC 114; (-)-DARUNAVIR; DTXSID0046779; UIC 94017; CHEBI:367163; TMC-41629; YO603Y8113; DTXCID8026779; Ethanolate, Darunavir; RefChem:585195

Frequently Asked Questions

What are the CAS number and molecular formula of Darunavir?

CAS 206361-99-1; molecular formula C27H37N3O7S; molecular weight — g/mol.

What other names is Darunavir known by?

Darunavir, 206361-99-1, TMC114, TMC-114, UIC-94017, Darunavirum.

Is Darunavir classified as hazardous?

Hazard statements reported: H315, H317, H319, H335.

What are the key physical properties of Darunavir?

Melting Point: 74-76; Melting Point: 74 °C (decomposes); Solubility: 6.68e-02 g/L; LogP: 1.89.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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