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Description

Darifenacin · CAS 133099-04-4 · C28H30N2O2. UNII APG9819VLM. Solubility: 2.98e-04 g/L; LogP: 4.5.

Identification

CAS Registry Number	133099-04-4
PubChem CID	444031
Molecular formula	C28H30N2O2
IUPAC name	2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
UNII (FDA)	APG9819VLM

Computed Descriptors

Molecular Weight	426.5
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	7
Exact Mass	426.230728204
Monoisotopic Mass	426.230728204
Topological Polar Surface Area	55.6
Heavy Atom Count	32
Formal Charge	0

Physical & Chemical Properties

Solubility	2.98e-04 g/L
LogP	4.5

Physical description & handling notes

• Solid

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.
• Darifenacin is an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome. Darifenacin has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
• Take with or without food. The absorption is unaffected by food.
• Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.

Synonyms

Darifenacin; 133099-04-4; 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide; UK-88525; darifenacine; Darifenacina; Darifenacin extended release; APG9819VLM; UK88525; (S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide; DTXSID2048290; CHEBI:391960; 2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide; 3-Pyrrolidineacetamide, 1-(2-(2,3-dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-, (3S)-; darifenicin; Darifenacinum

Frequently Asked Questions

What are the CAS number and molecular formula of Darifenacin?

CAS 133099-04-4; molecular formula C28H30N2O2; molecular weight — g/mol.

What other names is Darifenacin known by?

Darifenacin, 133099-04-4, 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide, UK-88525, darifenacine, Darifenacina.

What are the key physical properties of Darifenacin?

Solubility: 2.98e-04 g/L; LogP: 4.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.