双氯苯那胺

Description

dichlorphenamide · CAS 120-97-8 · C6H6Cl2N2O4S2. UNII VVJ6673MHY. Melting Point: 228.5; Melting Point: 239-241 °C; Melting Point: 228.7 °C.

Identification

CAS Registry Number	120-97-8
PubChem CID	3038
Molecular formula	C6H6Cl2N2O4S2
IUPAC name	4,5-dichlorobenzene-1,3-disulfonamide
UNII (FDA)	VVJ6673MHY

Computed Descriptors

Molecular Weight	305.2
XLogP3	0.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	303.9146044
Monoisotopic Mass	303.9146044
Topological Polar Surface Area	137
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	228.5
Melting Point	239-241 °C
Melting Point	228.7 °C
Solubility	3.98e-01 g/L
LogP	0.2
LogP	0.92
Dissociation Constants	PKA: 7.4, KA: 8.6

Physical description & handling notes

• Solid
• NEEDLES FROM DIMETHYLSULFOXIDE + WATER
• WHITE OR NEARLY WHITE, CRYSTALLINE POWDER
• SLIGHT CHARACTERISTIC ODOR
• PRACTICALLY INSOL IN WATER; SOL IN ALKALINE SOLN
• FREELY SOL IN PYRIDINE & IN 1 N NAOH; SOL IN ALCOHOL; SOL IN 2 N SODIUM CARBONATE; SLIGHTLY SOL IN ETHER

GHS Hazard Classification

Reported hazard statements	H315 (50%), H319 (50%), H361 (50%)

Documented Uses

• SCHULTZ, US PATENT 2,835,702 (1958 TO MERCK & CO).
• For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
• ...USED IN TREATMENT OF PRIMARY GLAUCOMA, ACUTE PHASE OF SECONDARY GLAUCOMA, & IN PREOPERATIVE CONTROL OF INTRAOCULAR TENSION. ... ALTHOUGH IT HAS DIURETIC PROPERTIES, IT IS NOT PROMOTED FOR THIS PURPOSE.
• ...DRUG HAS BEEN FOUND TO INHIBIT EPILEPTIC SEIZURES & TO DECR RATE OF SPINAL FLUID FORMATION. /ACETAZOLAMIDE/
• ...REDUCES RATE OF AQ HUMOR FORMATION; INTRAOCULAR PRESSURE IN PT WITH GLAUCOMA IS CORRESPONDINGLY REDUCED. THIS ACTION OF DRUG APPEARS TO BE INDEPENDENT OF SYSTEMIC ACID-BASE BALANCE. /ACETAZOLAMIDE/
• For more Therapeutic Uses (Complete) data for DICHLORPHENAMIDE (11 total), please visit the HSDB record page.

Synonyms

dichlorphenamide; Diclofenamide; 120-97-8; 4,5-dichlorobenzene-1,3-disulfonamide; Dichlorophenamide; Dichlofenamide; Daranide; Antidrasi; Glaucol; Oratrol; 1,3-Benzenedisulfonamide, 4,5-dichloro-; Dichlorphenamid; Diclofenamid; Diclofenamida; Diclofenamidum; 4,5-Dichloro-m-benzenedisulfonamide

Frequently Asked Questions

What are the CAS number and molecular formula of dichlorphenamide?

CAS 120-97-8; molecular formula C6H6Cl2N2O4S2; molecular weight — g/mol.

What other names is dichlorphenamide known by?

dichlorphenamide, Diclofenamide, 120-97-8, 4,5-dichlorobenzene-1,3-disulfonamide, Dichlorophenamide, Dichlofenamide.

Is dichlorphenamide classified as hazardous?

Hazard statements reported: H315, H319, H361.

What are the key physical properties of dichlorphenamide?

Melting Point: 228.5; Melting Point: 239-241 °C; Melting Point: 228.7 °C; Solubility: 3.98e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.