甲磺酸达拉非尼

甲磺酸达拉非尼（CAS 1195768-06-9）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• very slightly soluble at pH 1

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Dabrafenib is a selective inhibitor of mutated forms of BRAF kinase and is used alone or in combination with trametinib in the treatment of advanced malignant melanoma. Dabrafenib therapy is associated with transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors;
• Avoid grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum levels of dabrafenib.
• Avoid St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce serum levels of dabrafenib.
• Do not take with or immediately after a high-fat meal. Dabrafenib's bioavailability is reduced when taken with a high-fat meal.
• Take on an empty stomach. Take dabrafenib at least one hour before or two hours after a meal.

它在各数据库里的别名

Dabrafenib; 1195765-45-7; GSK2118436A; GSK2118436; GSK-2118436; GSK-2118436A; QGP4HA4G1B; CHEBI:75045; DTXSID20152499; N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; N-(3-(5-(2-AMINOPYRIMIDIN-4-YL)-2-TERT-BUTYL-1,3-THIAZOL-4-YL)-2-FLUOROPHENYL)-2,6-DIFLUOROBENZENESULFONAMIDE; N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; dabrafenibum; RefChem:58040; DTXCID8074990; BRAF Inhibitor GSK2118436

计算机算出的分子描述符

数据库摘要

dabrafenib mesylate · CAS 1195768-06-9 · C23H20F3N5O2S2. UNII QGP4HA4G1B. 沸点: 653.7; LogP: 2.9; Dissociation Constants: -1.5.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。