DL-鸟氨酸盐酸盐

Description

DL-Ornithine hydrochloride · CAS 1069-31-4 · C6H12F2N2O2. UNII ZQN1G5V6SR. Boiling Point: 347; Solubility: >10 mg/mL.

Identification

CAS Registry Number	1069-31-4
PubChem CID	3009
Molecular formula	C6H12F2N2O2
IUPAC name	2,5-diamino-2-(difluoromethyl)pentanoic acid
UNII (FDA)	ZQN1G5V6SR

Computed Descriptors

Molecular Weight	182.17
XLogP3	-2.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	182.08668395
Monoisotopic Mass	182.08668395
Topological Polar Surface Area	89.3
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Boiling Point	347
Solubility	>10 mg/mL

Physical description & handling notes

• MW: 236.65 /Eflornithine hydrochloride/
• Topical: Cream 13.9%, Veniqa (Skinmedica).

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Eflornithine is indicated to reduce the risk of relapse in adult and pediatric patients with high-risk neuroblastoma (HRNB) who have demonstrated at least a partial response to prior multiagent, multimodality therapy including anti-GD2 immunotherapy. It was also previously indicated for the treatment of female hirsutism and African trypanosomiasis but has since been discontinued.
• Breast Feeding; Lactation; Antiparasitic Agents; Antiprotozoal Agents; Enzyme Inhibitors; Trypanocidal Agents
• Medicines for the treatment of 2nd stage African trypanosomiasis
• Parenteral - General injections - IV: 200 mg per mL in 50 mL bottle (hydrochloride)

Synonyms

EFLORNITHINE; 70052-12-9; dfmo; 2-(Difluoromethyl)ornithine; 2,5-diamino-2-(difluoromethyl)pentanoic acid; Eflornitina; Eflornithinum; alpha-Difluoromethylornithine; 2-(Difluoromethyl)-DL-ornithine; alpha-(Difluoromethyl)-DL-ornithine; Ornithine, 2-(difluoromethyl)-; DL-alpha-Difluoromethylornithine; DL-Ornithine, 2-(difluoromethyl)-; ZQN1G5V6SR; CHEBI:41948; alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid

Frequently Asked Questions

What are the CAS number and molecular formula of DL-Ornithine hydrochloride?

CAS 1069-31-4; molecular formula C6H12F2N2O2; molecular weight — g/mol.

What other names is DL-Ornithine hydrochloride known by?

EFLORNITHINE, 70052-12-9, dfmo, 2-(Difluoromethyl)ornithine, 2,5-diamino-2-(difluoromethyl)pentanoic acid, Eflornitina.

What are the key physical properties of DL-Ornithine hydrochloride?

Boiling Point: 347; Solubility: >10 mg/mL.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.