多韦替尼

Description

Dovitinib · CAS 405169-16-6 · C21H21FN6O. UNII I35H55G906.

Identification

CAS Registry Number	405169-16-6
PubChem CID	135398510
Molecular formula	C21H21FN6O
IUPAC name	4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one
UNII (FDA)	I35H55G906

Computed Descriptors

Molecular Weight	392.4
XLogP3	1.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	392.17608748
Monoisotopic Mass	392.17608748
Topological Polar Surface Area	90.3
Heavy Atom Count	29
Formal Charge	0

Documented Uses

• Investigated for use/treatment in multiple myeloma and solid tumors.
• Unlike many kinase inhibitors that only target vascular endothelial growth factor (VEGF), Dovitinib inhibits receptors in the fibroblast growth factor (FGF ) pathway, as well as VEGF and platelet-derived growth factor (PDGF). FGF receptor tyrosine kinase inhibition is potentially of therapeutic significance to a group of myeloma patients whose cancer cells express high levels of surface FGF receptors.

Synonyms

Dovitinib; 405169-16-6; TKI-258; I35H55G906; GFKI-258; 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one; dovitinibum; 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl)-1,2-dihydroquinolin-2-one; RefChem:590385; 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one; Dovitinib [INN]; Chir 258; Dovitinib (TKI-258, CHIR-258); Dovitinib (TKI-258); Dovitinib lactate; 4-Amino-5-Fluoro-3-(6-(4-Methylpiperazin-1-yl)-1H-Benzo[D]Imidazol-2-yl)Quinolin-2(1H)-One

Frequently Asked Questions

What are the CAS number and molecular formula of Dovitinib?

CAS 405169-16-6; molecular formula C21H21FN6O; molecular weight — g/mol.

What other names is Dovitinib known by?

Dovitinib, 405169-16-6, TKI-258, I35H55G906, GFKI-258, 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.