迪马匹莫德

Description

Dilmapimod · CAS 444606-18-2 · C23H19F3N4O3. UNII Q3238VQW0N.

Identification

CAS Registry Number	444606-18-2
PubChem CID	10297982
Molecular formula	C23H19F3N4O3
IUPAC name	8-(2,6-difluorophenyl)-2-(1,3-dihydroxypropan-2-ylamino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7-one
UNII (FDA)	Q3238VQW0N

Computed Descriptors

Molecular Weight	456.4
XLogP3	3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	456.14092497
Monoisotopic Mass	456.14092497
Topological Polar Surface Area	98.6
Heavy Atom Count	33
Formal Charge	0

Documented Uses

• Dilmapimod has been used in trials studying the treatment and diagnostic of Nerve Trauma, Inflammation, Pain, Neuropathic, Arthritis, Rheumatoid, and Coronary Heart Disease, among others.
• Dilmapimod reduces the levels of proinflammatory cytokines and chemokines and reduce cellular infiltration to sites of inflammation, thereby reducing local damage. In diseases such as RA and IBD, TNFα blockade through either anti-TNFα antibodies or use of soluble TNFα receptors. Inhibition of p38α offers significant inhibition of TNFα, and cytokines such as IL-1β and IL-6, which offer additional therapeutic efficacy.

Synonyms

Dilmapimod; 444606-18-2; SB-681323; Q3238VQW0N; SB681323; DTXSID101318338; dilmapimodum; GW681323; RefChem:587981; DTXCID401748150; Dilmapimod [USAN:INN]; GW 681323; UNII-Q3238VQW0N; SB 681323; GSK 681323; SB-681323; GW 681323

Frequently Asked Questions

What are the CAS number and molecular formula of Dilmapimod?

CAS 444606-18-2; molecular formula C23H19F3N4O3; molecular weight — g/mol.

What other names is Dilmapimod known by?

Dilmapimod, 444606-18-2, SB-681323, Q3238VQW0N, SB681323, DTXSID101318338.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.