表阿霉素

表阿霉素（CAS 56420-45-2）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Solid
• Stable under recommended storage conditions. /Epirubicin hydrochloride/
• When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
• 215.2 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 226.33 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 224.59 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Antibiotics, Antineoplastic; Topoisomerase II Inhibitors
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
• Sicor developed a route from doxorubicin, in which the hydroxyl groups at C-9 and C-14 are protected as dioxanones (by reaction of doxorubicin with triethyl orthoformate), the 3'-amino group is protected as its N-trifluoroacetyl derivative, the hydroxyl groups of ring B as their trimethylsilyl derivatives, and the 4'-hydroxy group of the daunosamine residue is converted to a triflate group, which by nucleophilic substitution of the triflate by formate and then deprotection leads to /epirubicin/.
• The most direct route starts with the N-trifluoroacetyl derivative of daunorubicin, which is oxidized at very low temperature (-70 °C) with dimethylsulfoxide activated by trifluroacetanhydride to afford the 4'-keto derivative. Stereoselective reduction with sodium borohydride at -30 °C gives the 4'-epi-N-trifluoroacetyl daunorubicin, which after alkaline hydrolysis of the trifluoroacetyl group can be converted into /epirubicin/ ...

它在各数据库里的别名

Epirubicin; 56420-45-2; Epiadriamycin; Epidoxorubicin; 4'-Epiadriamycin; Epirubicine; 4'-epidoxorubicin; Epirubicina; Ridorubicin; Epirubicinum; Pidorubicina; Pidorubicine; Pidorubicinum; Farmorubicin; Epirubicinum [Latin]; Pidorubicin

计算机算出的分子描述符

数据库摘要

Epirubicin · CAS 56420-45-2 · C27H29NO11. UNII 3Z8479ZZ5X. 熔点: 344.53; 熔点: 344.53 °C; 溶解度: 0.093.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。