恩夫韦肽

恩夫韦肽（CAS 159519-65-0）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• White to off white amorphous solid
• Negligible solubility in pure water. In buffer pH 7.5, 85-142 mg/100 mL.
• Reconstituted solution should be stored under refrigeration at 2 to 8 °C (36 to 46 °F) and used within 24 hours.
• pKa = 4.25 (Glutamic acid side chains 5 in sequence); pKa = 10.5 (Lysine amino side chain 2 in sequence); pKa = 3.86 (Aspartic acid side chain 1 in sequence); pKa = 6.00 (Histidine side chain 1 in sequence)
• Parenteral: For injection: 108 mg Fuzeon (with sterile water for injection diluent), (Roche).

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Preparation ... D.P. Bolognesi et al, WO 94 28920; eidem, US 5464933 (1994, 1995 both to Duke University)
• Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS.
• Enfuvirtide is an HIV fusion inhibitor, the first of this class of agents active against the human immunodeficiency virus (HIV). Enfuvirtide has not been associated with serum aminotransferase elevations during therapy or episodes of acute, clinically apparent liver injury.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Fusion Inhibitors
• Subcutaneous injection of enfuvirtide has been associated with reactions at the site of administration, including mild to moderate pain/discomfort, induration, erythema, presence of nodules or cysts, pruritus, and ecchymosis, in up to 98% of patients. In clinical studies, injection site reactions occurred during the first week of therapy in 86% of patients; in most patients, the severity of these reactions did not change during the 24-week study. Individual injection site reactions persisted for longer than 7 days
• For more Drug Warnings (Complete) data for ENFUVIRTIDE (10 total), please visit the HSDB record page.

它在各数据库里的别名

Enfuvirtide; Pentafuside; Fuzeon; DP178; DP-178; Enfuvirtida; CHEBI:608828; Fuzeon T-20; 19OWO1T3ZE; DTXSID20166672; peptide T20; T20, Peptide; enfuvirtidum; RefChem:55093; DTXCID8089163; J05AX07

计算机算出的分子描述符

数据库摘要

Enfuvirtide · CAS 159519-65-0 · C204H301N51O64. UNII 19OWO1T3ZE. Hydrophobicity: -0.875.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。