埃维特拉韦

Description

Elvitegravir · CAS 697761-98-1 · C23H23ClFNO5. UNII 4GDQ854U53. Solubility: <0.3 mcg/mL.

Identification

CAS Registry Number	697761-98-1
PubChem CID	5277135
Molecular formula	C23H23ClFNO5
IUPAC name	6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid
UNII (FDA)	4GDQ854U53

Computed Descriptors

Molecular Weight	447.9
XLogP3	5.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	447.1248787
Monoisotopic Mass	447.1248787
Topological Polar Surface Area	87.1
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Solubility	<0.3 mcg/mL

Regulatory Status

GHS notification summary	33.3% (1 / 3)

GHS Hazard Classification

GHS notification summary	33.3% (1 / 3)
Reported hazard statements	H400 (33.3%), H410 (33.3%), H411 (33.3%), H412 (33.3%)

Documented Uses

• Elvitegravir in combination with an HIV protease inhibitor coadministered with ritonavir and with other antiretroviral drug(s) is indicated for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Integrase Inhibitors
• Avoid St. John's Wort. This herb induces the CYP3A metabolism of elvitegravir. Therefore, it may reduce the serum concentration of elvitegravir and its effectiveness.
• Take separate from antacids. Take at least 2 hours before or after antacids.
• Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
• Compounds which inhibit or antagonize biosynthesis or actions of integrase.

Synonyms

Elvitegravir; 697761-98-1; GS-9137; JTK-303; Vitekta; GS 9137; JTK 303; elvitegravirum; JTK303; CHEBI:72289; GS9137; 4GDQ854U53; DTXSID101021650; VITEKTA COMPONENT ELVITEGRAVIR; STRIBILD COMPONENT ELVITEGRAVIR; RefChem:58903

Frequently Asked Questions

What are the CAS number and molecular formula of Elvitegravir?

CAS 697761-98-1; molecular formula C23H23ClFNO5; molecular weight — g/mol.

What other names is Elvitegravir known by?

Elvitegravir, 697761-98-1, GS-9137, JTK-303, Vitekta, GS 9137.

Is Elvitegravir classified as hazardous?

33.3% of GHS notifications report no hazard classification (1 of 3).

What are the key physical properties of Elvitegravir?

Solubility: <0.3 mcg/mL.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.