厄达非替尼

厄达非替尼（CAS 1346242-81-6）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Erdafitinib is a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor that is indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma that has susceptible FGFR3 or FGFR2 genetic alterations and has progressed during or following at least one line of prior platinum-containing chemotherapy including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. The selection of patients for the treatment of locally advanced or metastatic
• Erdafitinib is an oral small molecule inhibitor of fibroblast growth factor (FGF) receptors 1 to 4 that is used in the therapy of locally advanced, unresectable or metastatic urothelial carcinoma. Erdafitinib has been associated with a high rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors
• Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of erdafitinib.
• Exercise caution with St. John's Wort. This herb induces the CYP3A metabolism of erdafitinib and may reduce its serum concentration.
• Take with or without food. No clinically meaningful differences with erdafitinib pharmacokinetics were observed following administration of a high-fat and high-calorie meal (800 calories to 1,000 calories with approximately 50% of total caloric content of the meal from fat) in healthy subjects.

它在各数据库里的别名

Erdafitinib; 1346242-81-6; Balversa; 890E37NHMV; DTXSID001027936; N'-(3,5-dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine; erdafitinibum; N'-(3,5-dimethoxyphenyl)-N'-(3-(1-methylpyrazol-4-yl)quinoxalin-6-yl)-N-propan-2-ylethane-1,2-diamine; RefChem:57639; DTXCID201513503; JNJ-42756493; N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine; MFCD28502040; Balversa (TN); ERDAFITINIB [WHO-DD]; JNJ 42756493

计算机算出的分子描述符

数据库摘要

Erdafitinib · CAS 1346242-81-6 · C25H30N6O2. UNII 890E37NHMV. 溶解度: <1 mg/mL.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。