氯霉素

Description

Chloramphenicol · CAS 56-75-7 · C11.H12.Cl2.N2.O5. UNII 66974FR9Q1. Melting Point: 171; Melting Point: 150.5-151.5 °C; Melting Point: MP: 149-153 °C.

Identification

CAS Registry Number	56-75-7
PubChem CID	5959
Molecular formula	C11.H12.Cl2.N2.O5
IUPAC name	2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
UNII (FDA)	66974FR9Q1

Computed Descriptors

Molecular Weight	323.13
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	322.0123269
Monoisotopic Mass	322.0123269
Topological Polar Surface Area	115
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	171
Melting Point	150.5-151.5 °C
Melting Point	MP: 149-153 °C
Melting Point	150.5 °C
Melting Point	151 °C
Solubility	2500
Solubility	In water, 2.5 mg/mL at 25 °C
Solubility	4.61e-01 g/L
LogP	1.14
LogP	log Kow = 1.14

Physical description & handling notes

• Needles or elongated plates from water or ethylene dichloride; [HSDB]
• Solid
• Needles or elongated plates from water or ethylene dichloride
• White to greyish-white or yellowish-white fine crystalline powder or fine crystals, needles or elongated plates. Of the four possible stereoisomers, only the alphaR,betaR (or D-threo) form is active ... .
• Pale yellow plates or needles from water
• Bitter to taste

Regulatory Status

Regulatory & Food Contact	ANTIMICROBIAL_AGENT: Veterinary Drug NO ADI ALLOCATED TRS 925-JECFA 62/49 FAS 53-JECFA 62/7
GHS notification summary	2% (6 / 294)

GHS Hazard Classification

GHS notification summary	2% (6 / 294)
Reported hazard statements	H317 (18%), H318 (11.6%), H350 (70.4%), H351 (27.2%), H360 (12.9%), H361 (41.2%), H341, H372

Documented Uses

• Broad-spectrum antibiotic; [HSDB]
• Anti-Bacterial Agents; Protein Synthesis Inhibitors
• Use (kg; approx.) in Germany (2009): >50
• Use (kg; exact) in Germany (2009): 68
• Consumption (g per capita; approx.) in Germany (2009): 0.000611
• Consumption (g per capita; exact) in Germany (2009): 0.00083

Synonyms

chloramphenicol; 56-75-7; Chlornitromycin; Levomycetin; Levomicetina; Chlorocid; Chloroamphenicol; Alficetyn; Chloramex; Globenicol; D-Chloramphenicol; Aquamycetin; Chemicetina; Chloramsaar; Chloronitrin; Enteromycetin

Frequently Asked Questions

What are the CAS number and molecular formula of Chloramphenicol?

CAS 56-75-7; molecular formula C11.H12.Cl2.N2.O5; molecular weight — g/mol.

What other names is Chloramphenicol known by?

chloramphenicol, 56-75-7, Chlornitromycin, Levomycetin, Levomicetina, Chlorocid.

What is the regulatory status of Chloramphenicol?

Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; NO ADI ALLOCATED; TRS 925-JECFA 62/49.

Is Chloramphenicol classified as hazardous?

2% of GHS notifications report no hazard classification (6 of 294).

What are the key physical properties of Chloramphenicol?

Melting Point: 171; Melting Point: 150.5-151.5 °C; Melting Point: MP: 149-153 °C; Melting Point: 150.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.